ABHD5 and TPD52L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABHD5	TPD52L2
Description		abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	TPD52 like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lipid Droplet Cytosol	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Triacylglycerol Lipase Activity Protein Binding Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity Lipase Activator Activity	RNA Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipid Catabolic Process Lipid Homeostasis	Carbohydrate Metabolic Process Regulation Of Cell Population Proliferation
Pathways		Triglyceride catabolism
Drugs			Phenethyl Isothiocyanate
Diseases		Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS		A body shape index ( 34021172) General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Prostate cancer ( 23535732)
Interacting Genes		21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12	10 interacting genes: ABHD5 ADORA2B APP CDC42 COQ8A MAL2 SH3GLB1 TPD52 TPD52L1 TPD52L3
Entrez ID		51099	7165
HPRD ID		11986	11947
Ensembl ID		ENSG00000011198	ENSG00000101150
Uniprot IDs		A0A0S2Z5D6 A0A2U3TZT9 C9J1D1 Q8WTS1	A0A087WYR3 A0A087WZ51 O43399 Q68E05 Q6FGS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Droplet Disassembly Lipid Droplet Positive Regulation Of Triglyceride Storage Acylglycerol Acyl-chain Remodeling Lipid Storage Lipid Droplet Organization Regulation Of Lipid Storage Cellular Response To Glucose Starvation Organelle Disassembly Positive Regulation Of Lipid Storage Glycerolipid Metabolic Process ADP Binding Protein Localization To Vacuolar Membrane Cellular Response To Starvation Response To Starvation Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity	Lysophosphatidic Acid Acyltransferase Activity Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Homodimerization Activity Phosphatidic Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Protein Localization To Vacuolar Membrane Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Cytokinesis GBD Domain Binding Storage Vacuole Negative Regulation Of Triglyceride Storage Lipase Activator Activity Positive Regulation Of Membrane Tubulation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Activity Relaxation Of Vascular Associated Smooth Muscle Regulation Of Vesicle-mediated Transport Regulation Of Interleukin-6 Production Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Axon Midline Choice Point Recognition Positive Regulation Of MAPK Cascade
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