HOXD10 and GEMIN2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HOXD10	GEMIN2
Name		homeobox D10	gem nuclear organelle associated protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Transcription Repressor Complex Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Single Fertilization Skeletal Muscle Tissue Development Adult Locomotory Behavior Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Spinal Cord Motor Neuron Cell Fate Specification Embryonic Limb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Peripheral Nervous System Neuron Development Neuromuscular Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing Protein-containing Complex Assembly
Pathways		None	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Diseases		Congenital vertical talus	None
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Creatinine levels ( 31015462 ) Estimated glomerular filtration rate ( 31015462 ) Kidney volume ( 34128465 ) Male-pattern baldness ( 28196072 )	Vitamin D levels ( 28757204 )
Novel Interactors		None recorded	1 novel interactors: AKAP6
Interacting Genes		7 interacting genes: CREBBP EP300 GEMIN2 GMNN HMGB1 PBX1 RCHY1	33 interacting genes: BEND7 DDX20 DHX9 FBXO7 GEMIN5 HOXD10 IKBKG INCA1 KPNA6 MEOX1 MTNR1A NUFIP1 PAX6 PSMB1 RN7SL1 RNU1-1 RNU2-1 RPP14 SMN1 SMN2 SNRNP70 SNRPD1 SNRPD2 SNRPD3 SNRPN SPG21 SRSF1 SRSF2 SRSF3 SRSF4 STXBP2 STXBP3 U2AF2
Entrez ID		3236	8487
HPRD ID		00867	03999
Ensembl ID		ENSG00000128710	ENSG00000092208
Uniprot IDs		P28358	A0A8J9FJK1 A0A8J9FN78 O14893
PDB IDs		Not available	2LEH 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Binding Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Damaged DNA Binding P53 Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Nucleoplasm Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Activation Of Innate Immune Response Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation Transcription Regulator Complex Lymphocyte Differentiation Transcription Coregulator Binding DNA Damage Response Tau Protein Binding Transcription Coactivator Activity Positive Regulation Of Binding Transcription Coactivator Binding Positive Regulation Of Innate Immune Response Mononuclear Cell Differentiation Protein Destabilization Canonical NF-kappaB Signal Transduction Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Transcription Repressor Complex Regulation Of Carbohydrate Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Nucleic Acid Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Leukocyte Differentiation Histone Crotonyltransferase Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity	RNA Splicing MRNA Processing SMN-Sm Protein Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Spliceosomal SnRNP Assembly RNA Metabolic Process MRNA Splicing, Via Spliceosome U1 SnRNP Spliceosomal Complex Assembly RNA Binding U2 SnRNP SMN Complex U4 SnRNP Nucleoplasm Nucleic Acid Metabolic Process Gemini Of Cajal Bodies Regulation Of MRNA Processing Small Nuclear Ribonucleoprotein Complex Protein-containing Complex Assembly Spliceosomal Complex U5 SnRNP Commitment Complex Regulation Of MRNA Splicing, Via Spliceosome PICln-Sm Protein Complex Protein-containing Complex Organization Nucleobase-containing Compound Metabolic Process 7-methylguanosine Cap Hypermethylation MRNA Binding Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing Methylosome Sequence-specific MRNA Binding Regulation Of MRNA Metabolic Process Nucleus U2-type Prespliceosome Nuclear Body DNA-templated Transcription Termination Precatalytic Spliceosome Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Tertiary Granule Nucleic Acid Binding Cellular Response To Cytokine Stimulus U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Cytoplasmic Ribonucleoprotein Granule