HOXD10 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 14973489)
0

Data Source:
HPRD (in vitro)

		HOXD10	GMNN
Description		homeobox D10	geminin DNA replication inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Transcription Repressor Complex Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Single Fertilization Skeletal Muscle Tissue Development Adult Locomotory Behavior Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Spinal Cord Motor Neuron Cell Fate Specification Embryonic Limb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Peripheral Nervous System Neuron Development Neuromuscular Process	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication
Pathways			Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases		Congenital vertical talus
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462) Kidney volume ( 34128465) Male-pattern baldness ( 28196072)	Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: CREBBP EP300 GEMIN2 GMNN HMGB1 PBX1 RCHY1	34 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		3236	51053
HPRD ID		00867	06783
Ensembl ID		ENSG00000128710	ENSG00000112312
Uniprot IDs		P28358	O75496
PDB IDs			1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Binding Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Damaged DNA Binding P53 Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Nucleoplasm Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Activation Of Innate Immune Response Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation Transcription Regulator Complex Lymphocyte Differentiation Transcription Coregulator Binding DNA Damage Response Tau Protein Binding Transcription Coactivator Activity Positive Regulation Of Binding Transcription Coactivator Binding Positive Regulation Of Innate Immune Response Mononuclear Cell Differentiation Protein Destabilization Canonical NF-kappaB Signal Transduction Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Transcription Repressor Complex Regulation Of Carbohydrate Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Nucleic Acid Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Leukocyte Differentiation Histone Crotonyltransferase Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity	Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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