Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
ZNF593 and MAP3K7
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
ZNF593
MAP3K7
Gene Name
zinc finger protein 593
mitogen-activated protein kinase kinase kinase 7
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleolus
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Cytoplasm
Cytosol
Plasma Membrane
IkappaB Kinase Complex
Endosome Membrane
Molecular Function
DNA Binding
Transcription Corepressor Activity
Metal Ion Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Scaffold Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Activation Of MAPKK Activity
Activation Of MAPK Activity
Angiogenesis
Neural Tube Formation
Toll-like Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
I-kappaB Phosphorylation
JNK Cascade
Positive Regulation Of Interleukin-2 Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Histone H3 Acetylation
Innate Immune Response
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
Downstream TCR signaling
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
TRAF6 mediated induction of TAK1 complex
Toll Like Receptor 7/8 (TLR7/8) Cascade
Signaling by Wnt
Toll Like Receptor TLR6:TLR2 Cascade
Downstream signaling events of B Cell Receptor (BCR)
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
FCERI mediated NF-kB activation
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
Cytokine Signaling in Immune system
MyD88-independent cascade
beta-catenin independent WNT signaling
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
TCR signaling
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Ca2+ pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Activation of NF-kappaB in B cells
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Fc epsilon receptor (FCERI) signaling
Interleukin-1 signaling
Adaptive Immune System
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Celiac disease (
20190752
)
Graves' disease (
21841780
)
Protein-Protein Interactions
7 interactors:
GPR3
LNX1
MAP3K7
MAPK8IP2
RAB1A
ZAK
ZNRD1
60 interactors:
BBS10
BCL10
CARD11
CHUK
COPS5
EIF2AK2
EZH2
FOS
GPR25
HGS
HIPK2
IKBKAP
IKBKB
IL17RD
IRAK1
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
NAIP
NDUFS6
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAA1
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
TAB1
TAB2
TGFBR1
TNFRSF11A
TRAF3IP2
TRAF6
TRIM8
VRK2
XIAP
ZNF593
ZNF746
Entrez ID
51042
6885
HPRD ID
15866
04011
Ensembl ID
ENSG00000135341
Uniprot IDs
O00488
O43318
PDB IDs
1ZR9
2EVA
2YIY
4GS6
4L3P
4L52
4L53
Enriched GO Terms of Interacting Partners
?
JNK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Regulation Of Stress-activated MAPK Cascade
MAPK Cascade
Signal Transduction By Phosphorylation
Activation Of MAPKK Activity
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Kinase Activity
Regulation Of JUN Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Kinase Activity
Positive Regulation Of Transferase Activity
Regulation Of Phosphorus Metabolic Process
Cellular Response To Stress
Positive Regulation Of JNK Cascade
Regulation Of MAPK Cascade
Interleukin-8 Secretion
Cargo Loading Into COPII-coated Vesicle
Activation Of MAPK Activity
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Interleukin-8 Production
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Nonassociative Learning
Positive Regulation Of Phosphorylation
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
Positive Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Cargo Loading Into Vesicle
Protein Complex Assembly
Activation Of Protein Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Growth Hormone Secretion
Cellular Protein Complex Assembly
Signal Complex Assembly
Positive Regulation Of Signal Transduction
I-kappaB Phosphorylation
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction By Phosphorylation
Signal Transduction
Regulation Of Phosphorylation
MAPK Cascade
Regulation Of Protein Metabolic Process
Signaling
Regulation Of Phosphorus Metabolic Process
Cell Communication
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of MAPK Cascade
Phosphorylation
Intracellular Signal Transduction
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Protein Phosphorylation
Toll-like Receptor 9 Signaling Pathway
Stress-activated MAPK Cascade
TRIF-dependent Toll-like Receptor Signaling Pathway
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Cellular Protein Metabolic Process
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Response To Stimulus
MyD88-dependent Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Phosphate-containing Compound Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Protein Modification Process
Response To Stimulus
Regulation Of MAP Kinase Activity
Regulation Of Kinase Activity
Positive Regulation Of Innate Immune Response
Tagcloud
?
abrogated
accounts
bcr
called
card
card11
carma1
existence
feedback
generating
ikappab
ikk
ikkbeta
implies
kappab
late
maguk
mathematical
modeling
module
nf
residue
scaffolding
serine
steep
switch
switchlike
tak1
threshold
Tagcloud (Difference)
?
abrogated
accounts
bcr
called
card
card11
carma1
existence
feedback
generating
ikappab
ikk
ikkbeta
implies
kappab
late
maguk
mathematical
modeling
module
nf
residue
scaffolding
serine
steep
switch
switchlike
tak1
threshold
Tagcloud (Intersection)
?