ZNF593 and ZAK

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF593	ZAK
Gene Name		zinc finger protein 593	sterile alpha motif and leucine zipper containing kinase AZK
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Nucleus Cytoplasm
	Molecular Function	DNA Binding Transcription Corepressor Activity Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated	Cell Cycle Checkpoint DNA Damage Checkpoint Activation Of MAPKK Activity Protein Phosphorylation Response To Stress Cytoskeleton Organization Cell Cycle Arrest Activation Of JUN Kinase Activity Cell Death Cell Proliferation Response To Radiation Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: GPR3 LNX1 MAP3K7 MAPK8IP2 RAB1A ZAK ZNRD1	27 interactors: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF746 ZNF775
Entrez ID		51042	51776
HPRD ID		15866	11791
Ensembl ID			ENSG00000091436
Uniprot IDs		O00488	D4Q8H0 Q9NYL2
PDB IDs		1ZR9
Enriched GO Terms of Interacting Partners?		JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade MAPK Cascade Signal Transduction By Phosphorylation Activation Of MAPKK Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Intracellular Signal Transduction Interleukin-8 Production Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Nonassociative Learning Positive Regulation Of Phosphorylation Positive Regulation Of MAP Kinase Activity Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Cargo Loading Into Vesicle Protein Complex Assembly Activation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Growth Hormone Secretion Cellular Protein Complex Assembly Signal Complex Assembly Positive Regulation Of Signal Transduction I-kappaB Phosphorylation	Cellular Response To Sorbitol Positive Regulation Of Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Toll-like Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Regulation Of Caveolin-mediated Endocytosis Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Cell Death Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Innate Immune Response Apoptotic Process Programmed Cell Death Positive Regulation Of MAP Kinase Activity Transcription, DNA-templated Positive Regulation Of Neuron Death Cellular Response To Carbohydrate Stimulus Positive Regulation Of Metabolic Process Intracellular Signal Transduction Cell Death
Tagcloud ?			adipogenic arresting associative ccpg1 chek chondrogenesis chondrogenic dedifferentiated dedifferentiation deriving dhcr24 dst g0s2 genechip hmga2 kat2 map2k6 maybe mll5 motivate msc osteogenesis prerequisites rassf4 rgs2 sesn3 transdifferentiate transdifferentiation unipotent
Tagcloud (Difference) ?			adipogenic arresting associative ccpg1 chek chondrogenesis chondrogenic dedifferentiated dedifferentiation deriving dhcr24 dst g0s2 genechip hmga2 kat2 map2k6 maybe mll5 motivate msc osteogenesis prerequisites rassf4 rgs2 sesn3 transdifferentiate transdifferentiation unipotent
Tagcloud (Intersection) ?