CACNB4 and SYT1

Number of citations of the paper that reports this interaction (PMID 16525042)
13

Data Source:
HPRD (two hybrid, in vivo)

		CACNB4	SYT1
Gene Name		calcium channel, voltage-dependent, beta 4 subunit	synaptotagmin I
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse	Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule SNARE Complex Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Protein Kinase Binding	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Clathrin Binding Identical Protein Binding Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Transport Cellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Axon Guidance Neuromuscular Junction Development Adult Walking Behavior Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Synaptic Transmission, Glutamatergic CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development Muscle Fiber Development T Cell Receptor Signaling Pathway Detection Of Light Stimulus Involved In Visual Perception Membrane Depolarization Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity	Detection Of Calcium Ion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Positive Regulation Of Synaptic Transmission Protein Homooligomerization Regulation Of Synaptic Transmission, Glutamatergic Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses	Dopamine Neurotransmitter Release Cycle Toxicity of botulinum toxin type G (BoNT/G) Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: CACNA1A CBX3 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3	30 interactors: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GNB2L1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17
Entrez ID		785	6857
HPRD ID		09057	01710
Ensembl ID		ENSG00000182389	ENSG00000067715
Uniprot IDs		E7DBM8 O00305	J3KQA0 P21579
PDB IDs		1VYV 2D46	2K45 2K4A 2K8M 2KI6 2LHA 2R83 3F00 3F01 3F04 3F05 4ISQ
Enriched GO Terms of Interacting Partners?		Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Chloride Ion Homeostasis Anion Homeostasis Regulation Of Calcium Ion-dependent Exocytosis Acid Secretion Cerebellar Molecular Layer Development Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotransmitter Secretion Vestibular Nucleus Development Cerebellum Maturation G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Musculoskeletal Movement, Spinal Reflex Action Endosomal Lumen Acidification Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Retinal Cell Programmed Cell Death Gamma-aminobutyric Acid Secretion Amino Acid Transport Neurotransmitter Transport Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Necroptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Inflammatory Cell Apoptotic Process Gamma-aminobutyric Acid Transport Regulation Of Neuron Apoptotic Process Cell-cell Signaling Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Hormone Biosynthetic Process Detection Of Calcium Ion Pons Development Regulation Of Neuron Death Positive Regulation Of Calcium Ion-dependent Exocytosis Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Cerebellar Purkinje Cell Differentiation Exocytosis T Cell Apoptotic Process Cerebellar Purkinje Cell Layer Morphogenesis Positive Regulation Of Vesicle Fusion Signaling Neurological System Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction Cell Communication Regulation Of Vesicle-mediated Transport Reflex PH Reduction	Cell-cell Signaling Neurotransmitter Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Vesicle Localization Regulation Of Cellular Localization Exocytosis Regulation Of Signaling Organelle Localization Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Signaling Establishment Of Vesicle Localization Regulation Of Cellular Component Organization Cell Communication Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Cellular Localization Establishment Of Organelle Localization Vesicle Fusion Vesicle-mediated Transport Membrane Depolarization Membrane Fusion Acid Secretion Regulation Of Vesicle-mediated Transport Protein Localization Regulation Of Protein Localization Regulation Of Membrane Potential Organelle Fusion Regulation Of Secretion Glucocorticoid Receptor Signaling Pathway Regulation Of Immune Response Vesicle Docking Transport Regulation Of Synaptic Transmission Establishment Of Protein Localization Membrane Docking Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Calcium Ion-dependent Exocytosis Regulation Of Protein Secretion Regulation Of Cellular Process Cell Differentiation Protein Transport Regulation Of Protein Localization To Plasma Membrane Membrane Organization
Tagcloud ?		altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage	carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Difference) ?		altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage	carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Intersection) ?