CAV3 and JPH2

Number of citations of the paper that reports this interaction (PubMedID 15541368)
0

Data Source:
HPRD (in vivo)

		CAV3	JPH2
Description		caveolin 3	junctophilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Membrane Z Disc T-tubule Neuromuscular Junction Vesicle Protein-containing Complex Sarcolemma Membrane Raft	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Junctional Membrane Complex Sarcoplasmic Reticulum Membrane
	Molecular Function	Calcium Channel Regulator Activity Protein Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Enzyme Binding Alpha-tubulin Binding Transmembrane Transporter Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding Molecular Adaptor Activity Connexin Binding	Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Phosphatidylserine Binding DNA Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	MAPK Cascade Response To Hypoxia Plasma Membrane Repair Regulation Of Heart Rate Response To Ischemia Cardiac Muscle Hypertrophy Triglyceride Metabolic Process Calcium Ion Transport Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Myotube Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Detection Of Muscle Stretch Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Cytosolic Calcium Ion Concentration Nucleus Localization Establishment Of Localization In Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Regulation Of Calcium Ion Import Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ionomycin Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Caveolin-mediated Endocytosis	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Negative Regulation Of DNA-templated Transcription Regulation Of Cardiac Muscle Tissue Development Calcium Ion Homeostasis Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Transport Into Cytosol
Pathways		Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD) Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Caudate activity during reward ( 28927378) Takayasu arteritis ( 33308445)	Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Cervical high-risk human papilloma virus infection (persistent) ( 33225922) Clozapine-induced agranulocytosis ( 25187353) Glomerular filtration rate (creatinine) ( 26831199) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418 27841878) Systolic blood pressure ( 30578418 30487518 29403010 27841878)
Interacting Genes		21 interacting genes: ADRB2 DAG1 DYSF EGFR GNAS INSR JPH2 KCNJ12 NOS1 PBX3 PCBP1 PDGFRA PDGFRB PFKM PTGES3 RBFA RYR1 SENP1 SLC22A11 SLC8A1 SNCA	1 interacting genes: CAV3
Entrez ID		859	57158
HPRD ID		03154	12006
Ensembl ID		ENSG00000182533	ENSG00000149596
Uniprot IDs		P56539	Q86VZ3 Q9BR39
PDB IDs			7RXE 7RXQ
Enriched GO Terms of Interacting Partners?		Regulation Of System Process Sarcolemma T-tubule Muscle System Process Regulation Of Monoatomic Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Transport Regulation Of Muscle Contraction Muscle Contraction Receptor Complex Regulation Of Metal Ion Transport System Process Negative Regulation Of Serotonin Uptake Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Regulation Of Calcium Ion Transport Regulation Of Serotonin Uptake Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Endothelial Growth Factor Binding Homeostatic Process Regulation Of Muscle System Process Sarcoplasmic Reticulum Membrane Positive Regulation Of The Force Of Heart Contraction Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Regulation Of Sequestering Of Calcium Ion Plasma Membrane Z Disc Glomerular Capillary Formation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Response To Growth Factor Positive Regulation Of Transport Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chemical Homeostasis Calcium-mediated Signaling Cellular Response To Oxygen-containing Compound Junctional Sarcoplasmic Reticulum Membrane Cellular Response To Caffeine Apical Plasma Membrane Positive Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Sarcoplasmic Reticulum Platelet-derived Growth Factor Binding Regulation Of Heart Contraction	Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of Sarcomere Organization Regulation Of Signal Transduction By Receptor Internalization Regulation Of Cell Size Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Thermosensory Behavior Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Monoatomic Ion Homeostasis Localization Within Membrane Regulation Of Caveolin-mediated Endocytosis Connexin Binding Intracellular Monoatomic Cation Homeostasis Caveola Assembly Positive Regulation Of Caveolin-mediated Endocytosis Potassium Channel Inhibitor Activity Inorganic Ion Homeostasis Plasma Membrane Raft Assembly Detection Of Muscle Stretch Monoatomic Cation Homeostasis Negative Regulation Of Cell Size Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cellular Component Size Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Metal Ion Transport Regulation Of Membrane Depolarization During Action Potential T-tubule Organization Cellular Response To Ionomycin Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sarcomere Organization Postsynaptic Neurotransmitter Receptor Diffusion Trapping Ammonium Transmembrane Transport Ammonium Channel Activity Potassium:chloride Symporter Activity Chloride:monoatomic Cation Symporter Activity Receptor Diffusion Trapping Intracellular Chloride Ion Homeostasis Nitric-oxide Synthase Binding Negative Regulation Of Protein Localization To Cell Surface Cellular Homeostasis Cellular Response To Ether Import Into Cell Hypotonic Response Membrane Raft Assembly Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Myotube Differentiation Heart Trabecula Formation Plasma Membrane Raft Organization Dendritic Spine Development
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