CAV3 and SLC22A11

Number of citations of the paper that reports this interaction (PMID 18985008)
2

Data Source:
HPRD (in vitro)

		CAV3	SLC22A11
Gene Name		caveolin 3	solute carrier family 22 (organic anion/urate transporter), member 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Z Disc T-tubule Neuromuscular Junction Vesicle Sarcolemma Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Channel Regulator Activity Protein Binding Protein C-terminus Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Protein Complex Binding Protein Complex Scaffold Alpha-tubulin Binding Ion Channel Binding Nitric-oxide Synthase Binding Connexin Binding	Inorganic Anion Exchanger Activity Protein Binding Organic Anion Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	Plasma Membrane Repair Regulation Of Heart Rate Negative Regulation Of Protein Kinase Activity Triglyceride Metabolic Process Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Protein Localization Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Cell Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Muscle Cell Cellular Homeostasis Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Nerve Growth Factor Receptor Activity Nucleus Localization Regulation Of Protein Kinase B Signaling Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Establishment Of Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Caveolin-mediated Endocytosis	Organic Anion Transport Urate Metabolic Process Transmembrane Transport
Pathways			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic anion transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs			Probenecid
Diseases
GWAS			Obesity-related traits ( 23251661) Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)
Protein-Protein Interactions		15 interactors: DAG1 DYSF EGFR GNAS INSR JPH2 NOS1 PCBP1 PDGFRA PDGFRB PFKM PTGES3 SENP1 SLC22A11 SLC8A1	3 interactors: CAV3 PDZK1 SLC9A3R1
Entrez ID		859	55867
HPRD ID		03154	06161
Ensembl ID		ENSG00000182533	ENSG00000168065
Uniprot IDs		P56539	Q9NSA0
PDB IDs
Enriched GO Terms of Interacting Partners?		Homeostatic Process Chemical Homeostasis Wound Healing Organ Morphogenesis Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process Positive Regulation Of The Force Of Heart Contraction Response To Wounding Positive Regulation Of Transport Exocrine System Development Regulation Of Calcium Ion Transport Positive Regulation Of Phospholipase C Activity Response To Organonitrogen Compound Glomerular Capillary Formation Cellular Response To Organonitrogen Compound Protein Autophosphorylation Cardiac Muscle Cell Development Positive Regulation Of DNA Replication Striated Muscle Cell Differentiation Metanephric Glomerulus Vasculature Development Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Metanephric Glomerulus Development Glomerulus Morphogenesis Regulation Of MAPK Cascade Regulation Of Cell Motility Interaction With Host Anatomical Structure Morphogenesis Tissue Development Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Cellular Component Movement Response To Organic Substance Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion	Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Ion Transport Regulation Of Protein Kinase B Signaling Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Localization To Plasma Membrane Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Renal Phosphate Ion Absorption Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of MAPK Cascade Cellular Protein Localization Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Plasma Membrane Organization Establishment Of Protein Localization To Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development T-tubule Organization Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Carboxylic Acid Transport Organic Acid Transport Protein Localization Renal Sodium Ion Transport Regulation Of Membrane Depolarization During Action Potential Cellular Phosphate Ion Homeostasis Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cardiac Muscle Cell Differentiation Protein Localization To Membrane Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Phosphorylation Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Caveolin-mediated Endocytosis Caveola Assembly Negative Regulation Of Intracellular Signal Transduction Endomembrane System Organization Negative Regulation Of Protein Localization To Cell Surface
Tagcloud ?		ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 urate zealand
Tagcloud (Difference) ?		ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 urate zealand
Tagcloud (Intersection) ?