CAMLG and PKHD1

Number of citations of the paper that reports this interaction (PubMedID 16243292)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CAMLG	PKHD1
Description		calcium modulating ligand	PKHD1 ciliary IPT domain containing fibrocystin/polyductin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex	Chromosome, Centromeric Region Extracellular Region Nucleus Chromosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium External Side Of Plasma Membrane Membrane Apical Plasma Membrane Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle 9+0 Non-motile Cilium
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Signaling Receptor Activity
	Biological Process	B Cell Homeostasis Receptor Recycling Defense Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Insertion Into ER Membrane Protein Stabilization Tail-anchored Membrane Protein Insertion Into ER Membrane	Establishment Of Mitotic Spindle Orientation Kidney Development Regulation Of Cell-matrix Adhesion Epithelial Cell Morphogenesis Intracellular Calcium Ion Homeostasis Positive Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of TOR Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Homeostatic Process Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cilium Assembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of Planar Polarity Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Cholangiocyte Proliferation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Cyclosporine Voclosporin
Diseases			Polycystic kidney disease
GWAS		Height ( 18391951)	Adult body size ( 32376654) Alcohol use disorder ( 30940813) Body size at age 10 ( 32376654) Caffeine consumption from coffee ( 33287642) Caffeine consumption from tea ( 33287642) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronotype ( 30696823) Coffee consumption ( 31046077) Diastolic blood pressure ( 27841878 28135244) Epigenetic age acceleration in alcohol use disorder ( 31466081) Estimated glomerular filtration rate ( 31152163) Fruit consumption ( 32066663) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intraocular pressure ( 30054594 29785010 29617998 29235454 24002674 31959993) Keratoconus ( 33649486) Longevity ( 30294719) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 17903305) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Tea consumption ( 31046077) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197) Weight loss (gastric bypass surgery) ( 23633212)
Interacting Genes		21 interacting genes: ADIPOQ AGR2 BCL2L13 EGFR ETNK1 F11R GET1 HSP90B1 HSPA13 KCNE4 LAT LCN2 OCIAD1 PBXIP1 PGRMC1 PKHD1 PPIB TMEM31 TNFRSF13B TXNDC12 VWC2	1 interacting genes: CAMLG
Entrez ID		819	5314
HPRD ID		03073	05987
Ensembl ID		ENSG00000164615	ENSG00000170927
Uniprot IDs		P49069	P08F94
PDB IDs		6SO5 8CR1
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Localization Within Membrane Positive Regulation Of Protein Localization To Plasma Membrane Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Protein Localization To Membrane Protein Localization To Cell Periphery Digestive Tract Morphogenesis Protein-containing Complex Smooth Endoplasmic Reticulum Regulation Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Localization To Membrane	Prostaglandin-I Synthase Activity B Cell Homeostasis Protein Insertion Into ER Membrane GET Complex Endoplasmic Reticulum Membrane Receptor Recycling Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Execution Phase Of Apoptosis Decidualization Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Purine-containing Compound Salvage Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway NAD+ Biosynthetic Process Response To Interleukin-6 Pyridine Nucleotide Biosynthetic Process Hydroperoxy Icosatetraenoate Dehydratase Activity NAD+ Biosynthetic Process Via The Salvage Pathway Purine Nucleotide Salvage Cellular Response To Interleukin-6 Prostaglandin Metabolic Process Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Prostanoid Metabolic Process NAD+ Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Receptor Metabolic Process Embryo Implantation Cellular Response To Interleukin-1 Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Lymphocyte Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Endoplasmic Reticulum Protein Insertion Into Membrane Caveola Negative Regulation Of Protein Ubiquitination ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Leukocyte Homeostasis Response To Interleukin-1 Negative Regulation Of Post-translational Protein Modification Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process
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