CAMLG and KCNE4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CAMLG	KCNE4
Description		calcium modulating ligand	potassium voltage-gated channel subfamily E regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex	Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	B Cell Homeostasis Receptor Recycling Defense Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Insertion Into ER Membrane Protein Stabilization Tail-anchored Membrane Protein Insertion Into ER Membrane	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Cyclosporine Voclosporin	Enflurane Promethazine Miconazole
Diseases
GWAS		Height ( 18391951)	Acute lymphoblastic leukemia (childhood) ( 19684603) Appendicular lean mass ( 33097823) Body mass index ( 20966902) Coronary artery disease in type 1 diabetes ( 32077919) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Fasting plasma glucose ( 32902719) Logical memory (delayed recall) in normal cognition ( 29274321) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Recurrent major depressive disorder x sex interaction ( 34099189) Reticulocyte count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		21 interacting genes: ADIPOQ AGR2 BCL2L13 EGFR ETNK1 F11R GET1 HSP90B1 HSPA13 KCNE4 LAT LCN2 OCIAD1 PBXIP1 PGRMC1 PKHD1 PPIB TMEM31 TNFRSF13B TXNDC12 VWC2	10 interacting genes: CAMLG FLNA GET3 KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TRDN TSNAX
Entrez ID		819	23704
HPRD ID		03073	09689
Ensembl ID		ENSG00000164615	ENSG00000152049
Uniprot IDs		P49069	Q8WWG9
PDB IDs		6SO5 8CR1
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Localization Within Membrane Positive Regulation Of Protein Localization To Plasma Membrane Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Protein Localization To Membrane Protein Localization To Cell Periphery Digestive Tract Morphogenesis Protein-containing Complex Smooth Endoplasmic Reticulum Regulation Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Localization To Membrane	GET Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Metal Ion Transport Regulation Of Muscle System Process Endoplasmic Reticulum Tail-anchored Membrane Protein Insertion Into ER Membrane Transmembrane Transporter Binding Regulation Of Membrane Potential Monoatomic Cation Transport Monoatomic Ion Transport Membrane Repolarization During Action Potential Delayed Rectifier Potassium Channel Activity Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Muscle Contraction Membrane Repolarization Detection Of Mechanical Stimulus Involved In Sensory Perception Protein Insertion Into ER Membrane Regulation Of Biological Quality Positive Regulation Of Potassium Ion Transport Response To Mechanical Stimulus Regulation Of Membrane Repolarization Regulation Of System Process Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Detection Of Mechanical Stimulus Renal Absorption Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Regulation Of Monoatomic Cation Transmembrane Transport Homeostatic Process Regulation Of Platelet Activation Voltage-gated Potassium Channel Activity Inorganic Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Perinuclear Region Of Cytoplasm Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Gastrin-induced Gastric Acid Secretion Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Protein Insertion Into Membrane Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Transport Neuronal Cell Body Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transport
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