RAF1 and BAD

Number of citations of the paper that reports this interaction (PMID 8929531)
377

Data Source:
HPRD (in vitro)

		RAF1	BAD
Gene Name		Raf-1 proto-oncogene, serine/threonine kinase	BCL2-associated agonist of cell death
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Pseudopodium	Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Phospholipid Binding Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase 2B Binding Protein Kinase B Binding Protein Heterodimerization Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Hypoxia Protein Phosphorylation Apoptotic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Heart Development Blood Coagulation Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Negative Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Somatic Stem Cell Maintenance Regulation Of Rho Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Motility	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Glucose Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Response To Estradiol Response To Progesterone Positive Regulation Of Glucokinase Activity Response To Testosterone Response To Oleic Acid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway Response To Drug Response To Hydrogen Peroxide Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Type B Pancreatic Cell Proliferation Innate Immune Response Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Response To Calcium Ion Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Cellular Response To Chromate Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Signaling by FGFR in disease MEK activation FCERI mediated MAPK activation CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling GP1b-IX-V activation signalling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Transmission across Chemical Synapses Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Ion channel transport GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation Activation of NMDA receptor upon glutamate binding and postsynaptic events RAF phosphorylates MEK Downstream signaling of activated FGFR Stimuli-sensing channels NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Post NMDA receptor activation events Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Activation of BH3-only proteins Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR NRAGE signals death through JNK Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Sorafenib Regorafenib Dabrafenib
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Cholesterol, total ( 20686565)	Mean platelet volume ( 22423221) Sarcoidosis ( 22837380)
Protein-Protein Interactions		123 interactors: ADCY6 AGTR1 AKT1 AR ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BIRC2 BIRC3 BRAF CCT3 CDC25A CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 ERBB2IP FYCO1 FYN GNB2 GNG4 GRB10 HRAS HSP90AA1 HSPA4 HSPA8 IL2RB INSR INTS10 JAK1 JAK2 KRAS KRT18 KRT8 KSR1 KSR2 LCK LRPAP1 MAP2K1 MAP2K2 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MRAS MYBPC1 MYC NEDD4 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRB PEBP1 PEBP4 PEX5L PHB PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 PURA RANBP9 RAP1A RAP2A RASD2 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TIMM50 TMEM70 TSC22D3 UBC UBE2D2 VAV1 VDAC1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1	43 interactors: AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CREB3L3 EWSR1 HRK KEAP1 MAP2K5 MAPK8 MCL1 PAK1 PAK7 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5894	572
HPRD ID		01265	04409
Ensembl ID		ENSG00000132155	ENSG00000002330
Uniprot IDs		B4E0X2 L7RRS6 P04049	Q92934
PDB IDs		1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL	1G5J
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Communication Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Response To Fibroblast Growth Factor Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of MAPK Cascade Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Programmed Cell Death Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Apoptotic Process Positive Regulation Of Phosphorylation Cell Death Death Positive Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Innate Immune Response Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Transferase Activity	Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Regulation Of Cellular Localization Phosphorylation Regulation Of Cellular Process Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Localization Cellular Response To Stress Regulation Of Cellular Protein Metabolic Process Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Signal Transduction Cellular Response To Stimulus Cell Communication Phosphate-containing Compound Metabolic Process
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
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