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RAF1 and ADCY6
Number of citations of the paper that reports this interaction (PMID
15470083
)
9
Data Source:
HPRD
(in vivo)
RAF1
ADCY6
Gene Name
Raf-1 proto-oncogene, serine/threonine kinase
adenylate cyclase 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrial Outer Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Pseudopodium
Plasma Membrane
Cilium
Membrane
Integral Component Of Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Small GTPase Binding
Mitogen-activated Protein Kinase Kinase Binding
Identical Protein Binding
Metal Ion Binding
Protein Heterodimerization Activity
Adenylate Cyclase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Metal Ion Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Response To Hypoxia
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Synaptic Transmission
Axon Guidance
Heart Development
Blood Coagulation
Cell Proliferation
Negative Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Platelet Activation
Negative Regulation Of Protein Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Ion Transmembrane Transport
Somatic Stem Cell Maintenance
Regulation Of Rho Protein Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Intermediate Filament Cytoskeleton Organization
Regulation Of Cell Differentiation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Transmembrane Transport
Death-inducing Signaling Complex Assembly
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cell Motility
Renal Water Homeostasis
Energy Reserve Metabolic Process
CAMP Biosynthetic Process
Water Transport
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Dopamine Receptor Signaling Pathway
Synaptic Transmission
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Activation Of Protein Kinase A Activity
Intracellular Signal Transduction
Small Molecule Metabolic Process
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Transmembrane Transport
Cellular Response To Glucagon Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Catecholamine Stimulus
Pathways
Signaling by GPCR
Signaling by FGFR in disease
MEK activation
FCERI mediated MAPK activation
CREB phosphorylation through the activation of Ras
Signaling by EGFRvIII in Cancer
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Rap1 signalling
Gastrin-CREB signalling pathway via PKC and MAPK
SOS-mediated signalling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
SHC-mediated signalling
Signaling by PDGF
DAP12 interactions
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
GP1b-IX-V activation signalling
Signaling by VEGF
Signalling to RAS
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Interleukin-2 signaling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Transmission across Chemical Synapses
Adaptive Immune System
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
Axon guidance
IRS-mediated signalling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
IRS-related events triggered by IGF1R
Ion channel transport
GRB2 events in ERBB2 signaling
VEGFR2 mediated cell proliferation
Activation of NMDA receptor upon glutamate binding and postsynaptic events
RAF phosphorylates MEK
Downstream signaling of activated FGFR
Stimuli-sensing channels
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Post NMDA receptor activation events
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
SOS-mediated signalling
SHC-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
SHC-related events
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
ARMS-mediated activation
RAF activation
SHC1 events in EGFR signaling
IRS-mediated signalling
FRS2-mediated cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by GPCR
Ca-dependent events
CaM pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Hedgehog 'off' state
Phospholipase C-mediated cascade
Integration of energy metabolism
Signaling by FGFR in disease
Activation of GABAB receptors
G alpha (s) signalling events
Signaling by EGFRvIII in Cancer
Adenylate cyclase activating pathway
PLCG1 events in ERBB2 signaling
DAP12 signaling
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Glucagon signaling in metabolic regulation
Signaling by PDGF
Calmodulin induced events
DAP12 interactions
PKA-mediated phosphorylation of CREB
Opioid Signalling
PKA activation
Aquaporin-mediated transport
EGFR interacts with phospholipase C-gamma
Adrenaline,noradrenaline inhibits insulin secretion
Signaling by ERBB2
Signaling by EGFR
PKA-mediated phosphorylation of CREB
GPCR downstream signaling
Calmodulin induced events
Downstream signal transduction
Signaling by EGFR in Cancer
PKA activation
Transmission across Chemical Synapses
DAG and IP3 signaling
CaM pathway
Downstream signaling of activated FGFR
Innate Immune System
GABA B receptor activation
GABA receptor activation
Adenylate cyclase inhibitory pathway
PKA activation in glucagon signalling
Signalling by NGF
PLC beta mediated events
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
Signaling by Ligand-Responsive EGFR Variants in Cancer
G-protein mediated events
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
Inhibition of adenylate cyclase pathway
Adenylate cyclase inhibitory pathway
Signaling by Hedgehog
PLC-gamma1 signalling
Drugs
Sorafenib
Regorafenib
Dabrafenib
Diseases
GWAS
Cardiac hypertrophy (
21348951
)
Cholesterol, total (
20686565
)
Protein-Protein Interactions
123 interactors:
ADCY6
AGTR1
AKT1
AR
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BIRC2
BIRC3
BRAF
CCT3
CDC25A
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
ERBB2IP
FYCO1
FYN
GNB2
GNG4
GRB10
HRAS
HSP90AA1
HSPA4
HSPA8
IL2RB
INSR
INTS10
JAK1
JAK2
KRAS
KRT18
KRT8
KSR1
KSR2
LCK
LRPAP1
MAP2K1
MAP2K2
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MRAS
MYBPC1
MYC
NEDD4
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRB
PEBP1
PEBP4
PEX5L
PHB
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
PURA
RANBP9
RAP1A
RAP2A
RASD2
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TIMM50
TMEM70
TSC22D3
UBC
UBE2D2
VAV1
VDAC1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
4 interactors:
ATXN1
CHRNA7
GNAS
RAF1
Entrez ID
5894
112
HPRD ID
01265
02621
Ensembl ID
ENSG00000132155
ENSG00000174233
Uniprot IDs
B4E0X2
L7RRS6
P04049
O43306
PDB IDs
1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Phosphorylation
Signal Transduction
Regulation Of Phosphorus Metabolic Process
Cell Communication
Signaling
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Response To Growth Factor
Response To Fibroblast Growth Factor
Cellular Response To Organic Substance
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Regulation Of MAPK Cascade
Response To Organic Substance
Neurotrophin TRK Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Programmed Cell Death
Neurotrophin Signaling Pathway
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Apoptotic Process
Positive Regulation Of Phosphorylation
Cell Death
Death
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Apoptotic Process
Regulation Of Cell Death
Positive Regulation Of Metabolic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Innate Immune Response
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Transferase Activity
Cognition
Activation Of Adenylate Cyclase Activity
Positive Regulation Of Adenylate Cyclase Activity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Lyase Activity
Regulation Of Adenylate Cyclase Activity
Positive Regulation Of CAMP Biosynthetic Process
Regulation Of Cyclase Activity
Positive Regulation Of CAMP Metabolic Process
Synaptic Transmission
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Regulation Of CAMP Biosynthetic Process
Regulation Of CAMP Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Death-inducing Signaling Complex Assembly
Post-embryonic Body Morphogenesis
Response To Organonitrogen Compound
Regulation Of Signal Transduction
Cell-cell Signaling
Regulation Of Signaling
Response To Abiotic Stimulus
Platelet Activation
Positive Regulation Of Metabolic Process
Neurological System Process
Positive Regulation Of Signal Transduction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Regulation Of Phosphorylation
Learning Or Memory
Activation Of Protein Kinase Activity
Response To Hypoxia
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Catalytic Activity
Cellular Response To Peptide
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Transmembrane Transport
Blood Coagulation
Hemostasis
Transport
Positive Regulation Of MAPK Cascade
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Single-organism Behavior
Response To Peptide Hormone
Cellular Response To Prostaglandin E Stimulus
Response To Parathyroid Hormone
Positive Regulation Of Protein Kinase Activity
Cellular Response To Organonitrogen Compound
Positive Regulation Of CAMP-mediated Signaling
Tagcloud
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pak2
pakl
phenomena
probed
proliferate
proto
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Difference)
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pak2
pakl
phenomena
probed
proliferate
proto
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Intersection)
?