PAX5 and TLK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAX5	TLK2
Description		paired box 5	tousled like kinase 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Nervous System Development Sensory Organ Development Lateral Ventricle Development Cerebral Cortex Development Cell Differentiation B Cell Differentiation Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis	Chromatin Organization Protein Phosphorylation DNA Damage Response Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Nucleus Localization Cellular Response To Gamma Radiation Regulation Of Chromatin Organization
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling
Drugs			Fostamatinib
Diseases		Lymphoplasmacytic lymphoma
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 30636644) Bipolar disorder ( 33169155) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) ghrelin levels ( 33852427) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)	Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		54 interacting genes: ACOT12 AIRIM BCAS2 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5	17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		5079	11011
HPRD ID		01334	10527
Ensembl ID		ENSG00000196092	ENSG00000146872
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	A0A804HJZ9 A0A804HK10 B4DUC2 J3QLK5 Q86UE8
PDB IDs		1K78 1MDM	5O0Y 7LO0
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding PML Body Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process G0 To G1 Transition Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Differentiation Enucleate Erythrocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Inhibitor Activity Ubiquitin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Hemopoiesis Positive Regulation Of RNA Metabolic Process Skeletal Muscle Cell Proliferation NLS-dependent Protein Nuclear Import Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of DNA Metabolic Process Identical Protein Binding Regulation Of DNA Recombination Positive Regulation Of Macrophage Differentiation	Chromatin Organization DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of Vacuole Organization Negative Regulation Of Autophagosome Assembly Histone Chaperone Activity Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Toll-like Receptor Signaling Pathway Chromatin Positive Regulation Of Metalloendopeptidase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding SUMO Conjugating Enzyme Activity Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Gamma-tubulin Binding Nucleus Regulation Of Autophagosome Assembly
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