PAX5 and TLE4

Number of citations of the paper that reports this interaction (PubMedID 10811620)
47

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PAX5	TLE4
Description		paired box 5	TLE family member 4, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Nervous System Development Sensory Organ Development Lateral Ventricle Development Cerebral Cortex Development Cell Differentiation B Cell Differentiation Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases		Lymphoplasmacytic lymphoma
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 30636644) Bipolar disorder ( 33169155) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) ghrelin levels ( 33852427) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Bipolar disorder ( 34099189) Bipolar disorder x sex interaction ( 34099189) Chronotype ( 30696823) Daytime nap ( 33568662) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting insulin ( 34059833) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Motion sickness ( 25628336) Neutrophil percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Platelet count ( 32888494) Plateletcrit ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Type 2 diabetes ( 30718926 32499647 30297969 28869590 26818947 24509480 22885922)
Interacting Genes		54 interacting genes: ACOT12 AIRIM BCAS2 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5	11 interacting genes: BRCA1 CRYAA CUX1 LIG4 MSX1 NUP62 OTX1 OTX2 PAX5 POU2F1 SRPK2
Entrez ID		5079	7091
HPRD ID		01334	05502
Ensembl ID		ENSG00000196092	ENSG00000106829
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	A0A994J7T6 Q04727
PDB IDs		1K78 1MDM
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding PML Body Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process G0 To G1 Transition Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Differentiation Enucleate Erythrocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Inhibitor Activity Ubiquitin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Hemopoiesis Positive Regulation Of RNA Metabolic Process Skeletal Muscle Cell Proliferation NLS-dependent Protein Nuclear Import Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of DNA Metabolic Process Identical Protein Binding Regulation Of DNA Recombination Positive Regulation Of Macrophage Differentiation	Chromatin Midbrain Development DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Forebrain Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Embryonic Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Sensory Organ Development Regulation Of Metabolic Process Condensed Chromosome Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Centrosome Cycle Regulation Of Centrosome Duplication Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Centrosome Cycle Establishment Of Integrated Proviral Latency Negative Regulation Of Odontoblast Differentiation DNA-binding Transcription Factor Activity Diencephalon Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process P53 Binding
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