PAX5 and ACOT12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAX5	ACOT12
Description		paired box 5	acyl-CoA thioesterase 12
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleoplasm Cytoplasm Cytosol Intercellular Bridge
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Acetyl-CoA Hydrolase Activity Protein Binding ATP Binding Lipid Binding Hydrolase Activity Thiolester Hydrolase Activity Identical Protein Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Nervous System Development Sensory Organ Development Lateral Ventricle Development Cerebral Cortex Development Cell Differentiation B Cell Differentiation Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis	Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling	Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases		Lymphoplasmacytic lymphoma
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 30636644) Bipolar disorder ( 33169155) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) ghrelin levels ( 33852427) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)	Bipolar disorder ( 31043756)
Interacting Genes		54 interacting genes: ACOT12 AIRIM BCAS2 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5	9 interacting genes: ACOT7 MEOX1 MEOX2 NAA10 NAA11 PAX5 PAX6 REL ZBTB8A
Entrez ID		5079	134526
HPRD ID		01334	16680
Ensembl ID		ENSG00000196092	ENSG00000172497
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	Q8WYK0
PDB IDs		1K78 1MDM	3B7K 4MOB 4MOC
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding PML Body Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process G0 To G1 Transition Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Differentiation Enucleate Erythrocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Inhibitor Activity Ubiquitin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Hemopoiesis Positive Regulation Of RNA Metabolic Process Skeletal Muscle Cell Proliferation NLS-dependent Protein Nuclear Import Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of DNA Metabolic Process Identical Protein Binding Regulation Of DNA Recombination Positive Regulation Of Macrophage Differentiation	Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Protein N-terminal-serine Acetyltransferase Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Somite Specification RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding NatA Complex Protein-N-terminal Amino-acid Acetyltransferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity HMG Box Domain Binding N-terminal Protein Amino Acid Acetylation Segment Specification Somite Development Sequence-specific DNA Binding Chromatin Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Embryonic Pattern Specification Regulation Of Transcription By RNA Polymerase II Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Long-chain Fatty-acyl-CoA Catabolic Process Palmitic Acid Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cerebral Cortex Development Pattern Specification Process Positive Regulation Of RNA Metabolic Process Sclerotome Development Habenula Development Pallium Development Medium-chain Fatty Acid Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Organ Morphogenesis Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification NF-kappaB Complex Long-chain Fatty Acyl-CoA Binding Medium-chain Fatty-acyl-CoA Metabolic Process Nucleus Forebrain Dorsal/ventral Pattern Formation Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion
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