PAX5 and GRHL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAX5	GRHL2
Description		paired box 5	grainyhead like transcription factor 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cell-cell Junction Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Nervous System Development Sensory Organ Development Lateral Ventricle Development Cerebral Cortex Development Cell Differentiation B Cell Differentiation Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis	In Utero Embryonic Development Neural Tube Closure Cardiac Ventricle Morphogenesis Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Cell Adhesion Brain Development Epidermis Development Regulation Of Gene Expression Neural Tube Development Keratinocyte Differentiation Respiratory Tube Development Cell Junction Assembly Multicellular Organism Growth Embryonic Digit Morphogenesis Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Cranial Skeleton Morphogenesis Face Development Lung Lobe Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching Anterior Neural Tube Closure Bicellular Tight Junction Assembly Epithelium Migration
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases		Lymphoplasmacytic lymphoma
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 30636644) Bipolar disorder ( 33169155) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) ghrelin levels ( 33852427) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)	Bronchopulmonary dysplasia ( 23897914) Chronic hepatitis B infection vs asymptomatic persistence ( 33736632) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		54 interacting genes: ACOT12 AIRIM BCAS2 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5	6 interacting genes: APP GRHL3 LMO4 PAX5 PAX6 PIAS2
Entrez ID		5079	79977
HPRD ID		01334	10545
Ensembl ID		ENSG00000196092	ENSG00000083307
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	B4DL28 Q6ISB3
PDB IDs		1K78 1MDM	5MR7
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding PML Body Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process G0 To G1 Transition Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Differentiation Enucleate Erythrocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Inhibitor Activity Ubiquitin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Hemopoiesis Positive Regulation Of RNA Metabolic Process Skeletal Muscle Cell Proliferation NLS-dependent Protein Nuclear Import Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of DNA Metabolic Process Identical Protein Binding Regulation Of DNA Recombination Positive Regulation Of Macrophage Differentiation	Central Nervous System Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding System Development Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Projection Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Cerebral Cortex Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Forebrain-midbrain Boundary Formation Chromatin DNA Binding Pancreatic A Cell Development Cell Fate Specification Tube Closure Neural Tube Closure Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process RNA Metabolic Process Acetylcholine Receptor Activator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?