PAX5 and CXorf38

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAX5	CXorf38
Description		paired box 5	chromosome X open reading frame 38
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Mitochondrion
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Nervous System Development Sensory Organ Development Lateral Ventricle Development Cerebral Cortex Development Cell Differentiation B Cell Differentiation Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases		Lymphoplasmacytic lymphoma
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 30636644) Bipolar disorder ( 33169155) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) ghrelin levels ( 33852427) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)
Interacting Genes		54 interacting genes: ACOT12 AIRIM BCAS2 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5	5 interacting genes: CDHR3 MEOX2 NFYC PAX5 PAX6
Entrez ID		5079	159013
HPRD ID		01334	06651
Ensembl ID		ENSG00000196092	ENSG00000185753
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	Q8TB03
PDB IDs		1K78 1MDM
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Nucleus DNA-binding Transcription Factor Binding PML Body Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process G0 To G1 Transition Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Differentiation Enucleate Erythrocyte Differentiation Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Inhibitor Activity Ubiquitin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Hemopoiesis Positive Regulation Of RNA Metabolic Process Skeletal Muscle Cell Proliferation NLS-dependent Protein Nuclear Import Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of DNA Metabolic Process Identical Protein Binding Regulation Of DNA Recombination Positive Regulation Of Macrophage Differentiation	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Cerebral Cortex Development Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Embryonic Organ Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Habenula Development Pallium Development DNA Binding Sensory Organ Development Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Somite Specification CCAAT-binding Factor Complex Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Formation Of Anatomical Boundary Iris Morphogenesis Glial Cell Fate Specification Positive Regulation Of Biosynthetic Process Type B Pancreatic Cell Differentiation Transcription By RNA Polymerase II Cornea Development In Camera-type Eye Salivary Gland Morphogenesis HMG Box Domain Binding Co-SMAD Binding Lateral Ventricle Development Regulation Of Timing Of Cell Differentiation Negative Regulation Of Neuroblast Proliferation Dorsal/ventral Axis Specification Regulation Of Development, Heterochronic Segment Specification Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription
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