GTPBP4 and COPB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GTPBP4	COPB1
Description		GTP binding protein 4	coat protein complex I subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Preribosome Binding	Structural Molecule Activity Protein Binding
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Osteoblast Differentiation Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Protein Stabilization	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport
Pathways			Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Height ( 28552196)	HDL cholesterol ( 26780889) HDL cholesterol levels ( 28334899 32203549) Height ( 31562340) High chromosomal aberration frequency (total) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)
Interacting Genes		8 interacting genes: COPB1 GGA1 GGA2 GGA3 PRKN SRPK2 USP7 YWHAG	46 interacting genes: ADAM19 ANO1 APP ARCN1 ARF1 BCAR1 COPE COPG1 COPG2 DSCR9 ERBIN FOXB1 GORAB GRB2 GTPBP4 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 KIAA1328 LINC00839 LZTS1 LZTS2 NUB1 PDGFRB PRKCE PTEN RGS2 RGS4 RHOQ RNF10 SERTAD1 SNTA1 SPTBN1 TANK TAPBP TMED10 TRIM37 TTYH2 UBC UBQLN4 VPS18 WBP2 XRCC6
Entrez ID		23560	1315
HPRD ID		09976	02981
Ensembl ID		ENSG00000107937	ENSG00000129083
Uniprot IDs		D2CFK9 Q9BZE4	P53618
PDB IDs		6LSS 6LU8 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Regulation Of Protein Stability Regulation Of Protein Catabolic Process Vesicle-mediated Transport To The Plasma Membrane Protein K6-linked Ubiquitination Intracellular Protein Localization Intracellular Protein Transport Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Trans-Golgi Network Vesicle-mediated Transport Intracellular Transport Presynapse Protein Stabilization Protein Catabolic Process Protein Localization To Cell Periphery Protein Localization To Organelle Establishment Of Protein Localization Golgi Apparatus Protein Destabilization Protein Localization To Lysosome Endosome Membrane Small GTPase Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Prostaglandin F Receptor Activity TORC1 Signaling Protein Localization To Membrane Protein-containing Complex Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Interleukin-2 Receptor Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination	COPI-coated Vesicle Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI Vesicle Coat COPI-coated Vesicle Transport Vesicle Golgi Vesicle Transport Vesicle-mediated Transport Golgi Membrane Negative Regulation Of Glycine Import Across Plasma Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Protein Localization Positive Regulation Of Reactive Oxygen Species Metabolic Process Golgi Apparatus Regulation Of Actin Cytoskeleton Organization Regulation Of Biological Quality Cytoplasmic Vesicle Regulation Of Actin Filament-based Process Endoplasmic Reticulum-Golgi Intermediate Compartment Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Cytoskeleton Organization Endoplasmic Reticulum Membrane Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Negative Regulation Of Organ Growth Intra-Golgi Vesicle-mediated Transport Peptide Antigen Binding Regulation Of Protein Metabolic Process Plasma Membrane Regulation Of Innate Immune Response Signaling Receptor Activator Activity Positive Regulation Of Macromolecule Biosynthetic Process Neuron Projection Organization Cytoplasm Positive Regulation Of Metabolic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cytokine Production Regulation Of Cellular Component Organization Membrane Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process Cellular Localization Regulation Of Intracellular Signal Transduction Intracellular Protein Localization Intracellular Protein Transport ER To Golgi Transport Vesicle Membrane Positive Regulation Of Tolerance Induction
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