GTPBP4 and GGA1

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		GTPBP4	GGA1
Description		GTP binding protein 4	golgi associated, gamma adaptin ear containing, ARF binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Preribosome Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Osteoblast Differentiation Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Protein Stabilization	Intracellular Protein Transport Golgi To Plasma Membrane Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Catabolic Process Protein Localization To Cell Surface Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Ciliary Membrane
Pathways			TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS		Height ( 28552196)	Health literacy ( 31250787)
Interacting Genes		8 interacting genes: COPB1 GGA1 GGA2 GGA3 PRKN SRPK2 USP7 YWHAG	48 interacting genes: ADRA2B AFTPH AP1AR AP1G1 APP ARF1 ARF3 ARF5 ATXN7L1 BACE1 BACE2 C1orf216 CCDC91 CDKL3 CDKN2A CFTR CLINT1 CLTC CSNK2A1 DGCR6L DTNB EGFR ETS1 F8 GGA2 GGA3 GTPBP4 GTSE1 IGF2R ING5 JUN LRP3 M6PR NPM1 RABEP1 RABGEF1 RNF11 RPS27A SMAD3 SORL1 SORT1 STAB1 SYNRG TOLLIP TP53 TSG101 UBC VPS18
Entrez ID		23560	26088
HPRD ID		09976	12078
Ensembl ID		ENSG00000107937	ENSG00000100083
Uniprot IDs		D2CFK9 Q9BZE4	Q9UJY5
PDB IDs		6LSS 6LU8 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2	1J2J 1JWF 1JWG 1NA8 1NAF 1NWM 1O3X 1OM9 1OXZ 1PY1 1UJJ 1UJK 1X79 2DWX 2DWY 3G2S 3G2T 3G2U 3G2V 3G2W
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Regulation Of Protein Stability Regulation Of Protein Catabolic Process Vesicle-mediated Transport To The Plasma Membrane Protein K6-linked Ubiquitination Intracellular Protein Localization Intracellular Protein Transport Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Trans-Golgi Network Vesicle-mediated Transport Intracellular Transport Presynapse Protein Stabilization Protein Catabolic Process Protein Localization To Cell Periphery Protein Localization To Organelle Establishment Of Protein Localization Golgi Apparatus Protein Destabilization Protein Localization To Lysosome Endosome Membrane Small GTPase Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Prostaglandin F Receptor Activity TORC1 Signaling Protein Localization To Membrane Protein-containing Complex Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Interleukin-2 Receptor Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination	Early Endosome Endosome Protein Transport Establishment Of Protein Localization Intracellular Protein Transport Vesicle-mediated Transport Intracellular Transport Cellular Localization Endosome Membrane Vacuolar Transport Establishment Of Localization In Cell Clathrin-coated Vesicle Lysosomal Transport Intracellular Protein Localization Trans-Golgi Network Recycling Endosome Endocytosis Golgi Apparatus Early Endosome Membrane Import Into Cell Post-Golgi Vesicle-mediated Transport Establishment Of Protein Localization To Vacuole Perinuclear Region Of Cytoplasm Golgi Vesicle Transport Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Protein Localization To Vacuole Protein Targeting To Vacuole Positive Regulation Of MiRNA Transcription Receptor-mediated Endocytosis Negative Regulation Of Protein Metabolic Process Trans-Golgi Network Membrane Positive Regulation Of MiRNA Metabolic Process Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Protein Targeting To Lysosome Enzyme Binding Regulation Of Cell Growth Clathrin-coated Pit Ubiquitin Protein Ligase Binding Retromer Complex Binding Regulation Of Vesicle-mediated Transport Golgi To Lysosome Transport Nuclear Envelope Lumen AP-1 Adaptor Complex Establishment Of Protein Localization To Organelle Late Endosome Regulation Of Cell Cycle Regulation Of Growth Protein-containing Complex
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