KLHL20 and BEX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL20	BEX1
Description		kelch like family member 20	brain expressed X-linked 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Transcription Coactivator Binding Signaling Receptor Binding Protein Binding Signaling Adaptor Activity Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	Signal Transduction Nervous System Development Cell Differentiation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)
Interacting Genes		81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT	31 interacting genes: AKT1 BAG4 BCAR3 CASP8 CHEK2 CNOT2 CTAG1A CTAG1B CYSRT1 FBXW7 FGFR2 FZR1 GSK3B KLHL20 KRT31 KRT34 MAGEA2 MAGEA2B MDFI MEOX2 NGFR OMP OTP PAX2 PICK1 PIK3CA PTEN PTPN11 SMAD4 TENM1 TEX11
Entrez ID		27252	55859
HPRD ID		13918	06460
Ensembl ID		ENSG00000076321	ENSG00000133169
Uniprot IDs		Q9Y2M5	Q9HBH7
PDB IDs		5YQ4 6GY5 8CIA
Enriched GO Terms of Interacting Partners?		Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I	Cellular Developmental Process Developmental Process Ubiquitin Protein Ligase Binding Positive Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Proteolysis Carbohydrate Homeostasis Positive Regulation Of Catalytic Activity Glucose Homeostasis Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination PML Body Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Catalytic Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Programmed Cell Death Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Intracellular Glucose Homeostasis Negative Regulation Of Protein Acetylation Animal Organ Development
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