KLHL20 and ARHGEF12

Number of citations of the paper that reports this interaction (PMID 21670212)
5

Data Source:
BioGRID (enzymatic study)

		KLHL20	ARHGEF12
Gene Name		kelch-like family member 20	Rho guanine nucleotide exchange factor (GEF) 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ACTA1 ARHGEF12 C14orf1 CORO7 CRMP1 CUL3 ECT2 EPAS1 GBP2 KIAA1377 LRIF1 LUC7L2 PIN1 PRMT6 SUV39H1	13 interactors: ABCA1 CD44 CUL3 GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 RHOA TEC
Entrez ID		27252	23365
HPRD ID		13918	09207
Ensembl ID		ENSG00000076321	ENSG00000196914
Uniprot IDs		Q9Y2M5	B4E2K6 E9PMR6 Q9NZN5
PDB IDs			1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokinesis Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytokinesis Anatomical Structure Morphogenesis Cell Morphogenesis Positive Regulation Of Rho GTPase Activity Regulation Of Cell Division Regulation Of Ras Protein Signal Transduction Regulation Of Rho GTPase Activity Cellular Component Assembly Actin Filament Organization Regulation Of Small GTPase Mediated Signal Transduction Cell Cycle Apoptotic Signaling Pathway Regulation Of Chromosome Segregation Histone H3-R2 Methylation Skeletal Muscle Fiber Adaptation Organelle Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Trophectodermal Cellular Morphogenesis Cellular Response To Oxygen Levels Positive Regulation Of Ras GTPase Activity Actomyosin Structure Organization Cell Differentiation Regulation Of Mitotic Nuclear Division Histone Methylation Positive Regulation Of Cell Division Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Cell Cycle Process Anatomical Structure Formation Involved In Morphogenesis Response To Abiotic Stimulus Cell Development Regulation Of Ras GTPase Activity Skeletal Muscle Thin Filament Assembly Histone H3-K9 Dimethylation Myoblast Fate Commitment Cytoskeleton Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Pyrimidine Nucleobase Catabolic Process Skeletal Myofibril Assembly Protein Methylation Actin Cytoskeleton Organization Skeletal Muscle Adaptation Adhesion Of Symbiont To Host	Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Signaling Cell Communication Regulation Of Cell Motility Anatomical Structure Morphogenesis Tissue Morphogenesis Regulation Of Ras Protein Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stimulus Positive Regulation Of Cytokinesis Regulation Of Cell Shape Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cytokinesis Rho Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Neuron Projection Development Regulation Of Catalytic Activity Positive Regulation Of Axonogenesis Positive Regulation Of Phospholipase Activity Regulation Of Protein Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Wound Healing Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Response To Wounding Positive Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Ossification Involved In Bone Maturation
Tagcloud ?		angiopoietin bioinformatic blocking candidates canonical corneae corneal correlating correspondingly dystrophic dystrophy ect2 grew incomplete kelch kleip limbus lymphatics microarrays microrna mir neovascular neovascularization options pharmaceutical player proangiogenic vegf vision	11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature
Tagcloud (Difference) ?		angiopoietin bioinformatic blocking candidates canonical corneae corneal correlating correspondingly dystrophic dystrophy ect2 grew incomplete kelch kleip limbus lymphatics microarrays microrna mir neovascular neovascularization options pharmaceutical player proangiogenic vegf vision	11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature
Tagcloud (Intersection) ?