KLHL20 and POLR3D

Number of citations of the paper that reports this interaction (PubMedID 26687681)
0

Data Source:
BioGRID (two hybrid)

		KLHL20	POLR3D
Description		kelch like family member 20	RNA polymerase III subunit D
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GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytosol
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Chromatin Binding
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	Immune System Process Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production TRNA Transcription By RNA Polymerase III Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)	Hypertriglyceridemia ( 23505323)
Interacting Genes		81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT	15 interacting genes: APEX1 ATF3 HNRNPAB HOXA10 HOXC9 KLHL20 MAPK11 MSX2 NR2E3 OGT POLR3E RBFOX2 RHOXF2 TAB1 ZNF496
Entrez ID		27252	661
HPRD ID		13918	01755
Ensembl ID		ENSG00000076321	ENSG00000168495
Uniprot IDs		Q9Y2M5	P05423
PDB IDs		5YQ4 6GY5 8CIA	7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I	Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Proximal/distal Pattern Formation Anterior/posterior Pattern Specification Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Pyroptotic Inflammatory Response Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Base-excision Repair Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Type II Interferon Binding Intracellular Receptor Signaling Pathway Transcription Regulator Complex DNA-(abasic Site) Binding Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity CHOP-ATF3 Complex Regionalization Protein K33-linked Ubiquitination Steroid Hormone Receptor Signaling Pathway
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