ARHGEF4 and KHDRBS1

Number of citations of the paper that reports this interaction (PubMedID 22745667)
76

Data Source:
BioGRID (unspecified method)

		ARHGEF4	KHDRBS1
Description		Rho guanine nucleotide exchange factor 4	KH RNA binding domain containing, signal transduction associated 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity Protein Tyrosine Kinase Binding
	Biological Process	Lamellipodium Assembly Intracellular Signal Transduction Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Cell Surface Receptor Signaling Pathway Spermatogenesis Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Regulation Of Cell Cycle
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Congenital left-sided heart lesions ( 33201861) Degraded stimulus continuous performance test score ( 31596458) Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) ( 26222057)	Body mass index ( 26426971)
Interacting Genes		7 interacting genes: APC CDC42 HLA-B HSF2BP KHDRBS1 RAC1 RHOA	116 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CEBPA CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 DSCAM EFEMP1 EMG1 FGR FNBP4 FRK FXR1 FXR2 FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OGT OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SHANK3 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC USP7 VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6
Entrez ID		50649	10657
HPRD ID		05559	03926
Ensembl ID		ENSG00000136002	ENSG00000121774
Uniprot IDs		E7EV07 Q9NR80	Q07666
PDB IDs		2DX1 2PZ1 3NMX 3NMZ	2XA6 3QHE 7Z89 7Z8A 7Z9A 7Z9B 7ZAB 7ZAC 7ZAF 7ZAM
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Wnt Signaling Pathway Protein Kinase Binding Cell Junction Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Lamellipodium Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Assembly G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Positive Regulation Of Protein Metabolic Process Leading Edge Membrane Ruffle Membrane Beta-catenin Destruction Complex Cell-matrix Adhesion Cell Periphery Regulation Of Stress Fiber Assembly Secretory Granule Membrane Endothelial Tube Morphogenesis Thioesterase Binding Neuron Fate Determination Wnt Signalosome Positive Regulation Of Pseudopodium Assembly Midbrain Dopaminergic Neuron Differentiation Regulation Of Supramolecular Fiber Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Cell Migration Cell-cell Junction Assembly Focal Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Neuron Migration Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Cell Motility Regulation Of Cell Cycle Establishment Of Apical/basal Cell Polarity Positive Regulation Of Organelle Organization Cell-substrate Adhesion Polarized Epithelial Cell Differentiation Positive Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity GTP-dependent Protein Binding Embryonic Heart Tube Development Positive Regulation Of Cellular Component Biogenesis Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Cytoplasm Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell-cell Junction Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway SH3 Domain Binding Protein Binding Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signal Transduction T Cell Receptor Signaling Pathway T Cell Costimulation Regulation Of Endocytosis Fc-gamma Receptor Signaling Pathway Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphorylation Regulation Of Transport Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Developmental Process Regulation Of Immune Response Immune System Process Ionotropic Glutamate Receptor Binding Endocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ephrin Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?