ARHGEF4 and KHDRBS1

Number of citations of the paper that reports this interaction (PMID 22745667)
1

Data Source:
BioGRID (unspecified method)

		ARHGEF4	KHDRBS1
Gene Name		Rho guanine nucleotide exchange factor (GEF) 4	KH domain containing, RNA binding, signal transduction associated 1
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Gene Ontology Annotations	Cellular Component	Cytosol Ruffle Membrane	Nucleus Nucleoplasm Cytoplasm Membrane Grb2-Sos Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding Rac Guanyl-nucleotide Exchange Factor Activity	DNA Binding RNA Binding SH3/SH2 Adaptor Activity Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Transcription, DNA-templated MRNA Processing Cell Cycle Arrest Signal Transduction Cell Surface Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APC HLA-B KHDRBS1 RAC1 RHOA	109 interactors: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK BZRAP1 CBL CD2AP CDK1 CIRBP CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 EFEMP1 EMG1 FGR FNBP4 FRK FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MIA2 MPP6 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OSTF1 PACSIN1 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RBMX RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SSFA2 STAT3 STUB1 TBL1X TJP1 TNFSF11 TUBB3 U2AF2 UBA52 UBASH3B VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6
Entrez ID		50649	10657
HPRD ID		05559	03926
Ensembl ID		ENSG00000136002	ENSG00000121774
Uniprot IDs		Q9NR80 Q9NTG0	Q07666
PDB IDs		2DX1 2PZ1 3NMX 3NMZ	2XA6 3QHE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Stress Fiber Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Cell Differentiation Apical Junction Assembly Viral Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Cytokinesis Neuron Projection Morphogenesis Positive Regulation Of Nucleocytoplasmic Transport Mitotic Cell Cycle Process Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Cell-cell Junction Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Division Mitotic Cell Cycle Cell Cycle Arrest Neuron Projection Development Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of RNA Export From Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Complex Assembly Cell Motility Regulation Of Organelle Organization Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Peptidyl-tyrosine Autophosphorylation Innate Immune Response Signal Transduction Immune Response-regulating Signaling Pathway Immune Response Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Locomotion Movement Of Cell Or Subcellular Component Cellular Response To Stimulus Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Phagocytosis Cellular Response To Peptide Positive Regulation Of Immune System Process Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cell Differentiation Regulation Of Catalytic Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Component Organization Immune System Process Response To Stimulus Regulation Of Signaling Cell Projection Organization Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Metabolic Process
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