ARHGEF4

Description		Rho guanine nucleotide exchange factor 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Lamellipodium Assembly Intracellular Signal Transduction Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Congenital left-sided heart lesions ( 33201861) Degraded stimulus continuous performance test score ( 31596458) Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab) ( 26222057)
Novel Interacting Genes		1 novel interacting genes: CTNNB1
Interacting Genes		7 interacting genes: APC CDC42 HLA-B HSF2BP KHDRBS1 RAC1 RHOA
Entrez ID		50649
HPRD ID		05559
Ensembl ID		ENSG00000136002
Uniprot IDs		E7EV07 Q9NR80
PDB IDs		2DX1 2PZ1 3NMX 3NMZ
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Wnt Signaling Pathway Protein Kinase Binding Cell Junction Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Lamellipodium Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Assembly G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Positive Regulation Of Protein Metabolic Process Leading Edge Membrane Ruffle Membrane Beta-catenin Destruction Complex Cell-matrix Adhesion Cell Periphery Regulation Of Stress Fiber Assembly Secretory Granule Membrane Endothelial Tube Morphogenesis Thioesterase Binding Neuron Fate Determination Wnt Signalosome Positive Regulation Of Pseudopodium Assembly Midbrain Dopaminergic Neuron Differentiation Regulation Of Supramolecular Fiber Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Cell Migration Cell-cell Junction Assembly Focal Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Neuron Migration Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Cell Motility Regulation Of Cell Cycle Establishment Of Apical/basal Cell Polarity Positive Regulation Of Organelle Organization Cell-substrate Adhesion Polarized Epithelial Cell Differentiation Positive Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity GTP-dependent Protein Binding Embryonic Heart Tube Development Positive Regulation Of Cellular Component Biogenesis Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity
Tagcloud ?