PRPF8 and SERPINB2

Number of citations of the paper that reports this interaction (PubMedID 15346200)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		PRPF8	SERPINB2
Description		pre-mRNA processing factor 8	serpin family B member 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cornified Envelope Extracellular Region Extracellular Space Cytoplasm Plasma Membrane
	Molecular Function	RNA Binding Protein Binding Peptidase Activity U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding Metal-dependent Deubiquitinase Activity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor	Fibrinolysis Negative Regulation Of Apoptotic Process
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Urokinase Tenecteplase Lanoteplase
Diseases		Retinitis pigmentosa (RP)
GWAS		Calcium levels ( 20705733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)	Asthma ( 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hen's egg allergy ( 29051540) Hip circumference adjusted for BMI ( 28552196) Systolic blood pressure ( 29208002)
Interacting Genes		21 interacting genes: ABCA1 DHX9 DSCAM DUX4 ERG GPKOW H2BC5 HNRNPH2 NEDD4 PIN1 PTEN RNF20 SERPINB2 SLC22A2 SND1 SUMO2 TP53 UBC UBE2I USP7 ZNF830	8 interacting genes: APP CDC42 IRF3 PLAU PRPF8 PSMB1 RB1 UBE3A
Entrez ID		10594	5055
HPRD ID		06295	01420
Ensembl ID		ENSG00000174231	ENSG00000197632
Uniprot IDs		Q6P2Q9	P05120
PDB IDs		3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6S8Q 6S9I 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS2 7PJH 7PX3 7QTT 7W59 7W5A 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD	1BY7 1JRR 2ARQ 2ARR
Enriched GO Terms of Interacting Partners?		Postsynaptic Cytosol PML Body Nucleoplasm Phosphothreonine Residue Binding Macromolecule Metabolic Process Rhythmic Process Nucleus RISC Complex Binding Phosphoserine Residue Binding MRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Modification Process Ubiquitin Ligase Activator Activity P53 Binding Regulation Of Telomere Capping Protein Tag Activity Protein Modification By Small Protein Conjugation RNA Polymerase Binding Synapse Organization Protein Stabilization Regulation Of Cell Cycle Process Regulation Of Cell Cycle SUMO Transferase Activity RNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Circadian Behavior Rhythmic Behavior Regulation Of Telomere Maintenance Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Presynaptic Cytosol Osteoblast Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Binding Regulation Of Phosphorus Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Viral Process Central Nervous System Development Sphingolipid Floppase Activity 3'-5' DNA/RNA Helicase Activity Nuclear Body DNA-templated Viral Transcription Negative Regulation Of Catabolic Process	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Apoptotic Process Cell Projection Morphogenesis Growth Cone Lamellipodium Regulation Of Growth Neuron Projection Organization Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Regulation Of Signal Transduction Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Programmed Cell Death Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Neuron Projection Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Receptor Ligand Activity Endocytosis Cell Surface Receptor Signaling Pathway Regulation Of Inflammatory Response Lipoprotein Particle Cell Projection Organization Positive Regulation Of Cell Cycle Cell Death Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response
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