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PRPF8 and DHX9
Number of citations of the paper that reports this interaction (PMID
22939629
)
44
Data Source:
BioGRID
(biochemical)
HPRD
(in vivo)
PRPF8
DHX9
Gene Name
pre-mRNA processing factor 8
DEAH (Asp-Glu-Ala-His) box helicase 9
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
U5 SnRNP
Membrane
Nuclear Speck
Catalytic Step 2 Spliceosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Membrane
Ribonucleoprotein Complex
Cytoplasmic Ribonucleoprotein Granule
CRD-mediated MRNA Stability Complex
Molecular Function
Protein Binding
U6 SnRNA Binding
U5 SnRNA Binding
Poly(A) RNA Binding
K63-linked Polyubiquitin Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
RNA Helicase Activity
ATP-dependent DNA Helicase Activity
ATP-dependent RNA Helicase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Biological Process
Spliceosomal Tri-snRNP Complex Assembly
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Splicing
Gene Expression
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
RNA Processing
Circadian Rhythm
RNA Splicing
Gene Expression
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Cellular Response To Heat
Innate Immune Response
CRD-mediated MRNA Stabilization
Pathways
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
mRNA Splicing
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
Processing of Capped Intron-Containing Pre-mRNA
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
mRNA Splicing - Major Pathway
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Calcium levels (
20705733
)
Protein-Protein Interactions
14 interactors:
ABCA1
DHX9
EFTUD2
ERG
GPKOW
HNRNPH2
NEDD4
PIN1
PRPF19
SERPINB2
SND1
SNRNP200
UBC
ZNF830
40 interactors:
ACTA1
AKAP8L
APBB1
BRCA1
DDX20
DDX5
EIF2AK2
EWSR1
GEMIN2
GEMIN4
GTF2B
H2AFX
HDLBP
HNRNPC
HNRNPK
IL7R
ILF3
JUN
KHDRBS1
MBD2
MGEA5
NXF1
PCNA
POLR2A
PRMT1
PRPF40A
PRPF8
RBM4
RELA
SMN1
SMN2
SNRPB
SNRPB2
SRPK1
SSRP1
STAU1
TBP
TOP2A
UBE2I
YWHAQ
Entrez ID
10594
1660
HPRD ID
06295
04386
Ensembl ID
ENSG00000174231
ENSG00000135829
Uniprot IDs
Q6P2Q9
B3KU66
Q08211
PDB IDs
3E9L
3ENB
3LRU
4JK7
4JK8
4JK9
4JKA
4JKB
4JKC
4JKD
4JKE
4JKF
4JKG
4JKH
4KIT
3LLM
3VYX
3VYY
Enriched GO Terms of Interacting Partners
?
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Splicing
MRNA Processing
MRNA Metabolic Process
RNA Processing
Regulation Of Type I Interferon Production
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Osteoblast Differentiation
DNA Damage Checkpoint
Blastocyst Growth
Protein Polyubiquitination
RNA Metabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Protein K63-linked Ubiquitination
Regulation Of Potassium Ion Transmembrane Transport
Response To Stress
Gene Expression
Nucleobase-containing Compound Metabolic Process
Cell Cycle Checkpoint
Negative Regulation Of Type I Interferon Production
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Ossification
Cellular Nitrogen Compound Metabolic Process
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Potassium Ion Transport
Spliceosomal Complex Assembly
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Generation Of Catalytic Spliceosome For First Transesterification Step
Negative Regulation Of Potassium Ion Export
Transmission Of Virus
Development Involved In Symbiotic Interaction
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Type I Interferon Production
Nitrogen Compound Metabolic Process
Cis Assembly Of Pre-catalytic Spliceosome
Regulation Of Heart Rate By Hormone
Cellular Metabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Stress
Signal Transduction In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Negative Regulation Of Ion Transport
Regulation Of Mitotic Cell Cycle
MRNA Processing
RNA Splicing
MRNA Metabolic Process
RNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Spliceosomal SnRNP Assembly
Nitrogen Compound Metabolic Process
Regulation Of Viral Process
Regulation Of Viral Genome Replication
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Viral Process
Positive Regulation Of DNA Metabolic Process
Regulation Of Gene Expression
Ribonucleoprotein Complex Assembly
Viral Process
Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Cellular Macromolecular Complex Assembly
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Ribonucleoprotein Complex Biogenesis
Negative Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Chromosome Organization
Positive Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Viral Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Viral Genome Replication
Tagcloud
?
abcb7
advance
alas2
asxl1
bclaf1
brca1
causal
cbl
cd34
december
deregulation
disruption
doi
erythroid
exon
hnrnpd
leu
link
online
pathophysiology
publication
rars
refractory
sf3b1
sideroblasts
slc25a37
splicing
transcript
transcriptome
Tagcloud (Difference)
?
abcb7
advance
alas2
asxl1
bclaf1
brca1
causal
cbl
cd34
december
deregulation
disruption
doi
erythroid
exon
hnrnpd
leu
link
online
pathophysiology
publication
rars
refractory
sf3b1
sideroblasts
slc25a37
splicing
transcript
transcriptome
Tagcloud (Intersection)
?