PRPF8 and HNRNPH2

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF8	HNRNPH2
Gene Name		pre-mRNA processing factor 8	heterogeneous nuclear ribonucleoprotein H2 (H)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm U5 SnRNP Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Membrane Ribonucleoprotein Complex
	Molecular Function	Protein Binding U6 SnRNA Binding U5 SnRNA Binding Poly(A) RNA Binding K63-linked Polyubiquitin Binding	Nucleotide Binding RNA Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		14 interactors: ABCA1 DHX9 EFTUD2 ERG GPKOW HNRNPH2 NEDD4 PIN1 PRPF19 SERPINB2 SND1 SNRNP200 UBC ZNF830	20 interactors: DDX5 GNB2L1 HNRNPA0 HNRNPUL1 ILF3 MSI2 PQBP1 PRMT6 PRPF31 PRPF8 QKI RAD21 RBFOX2 RBM10 RBM39 RBM4 SF1 SNRPC TEKT1 WDR83
Entrez ID		10594	3188
HPRD ID		06295	03022
Ensembl ID		ENSG00000174231	ENSG00000126945
Uniprot IDs		Q6P2Q9	P55795
PDB IDs		3E9L 3ENB 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT	1WEZ 1WG5
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of Type I Interferon Production Negative Regulation Of Cellular Response To Growth Factor Stimulus Osteoblast Differentiation DNA Damage Checkpoint Blastocyst Growth Protein Polyubiquitination RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transport Response To Stress Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Type I Interferon Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ossification Cellular Nitrogen Compound Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Potassium Ion Transport Spliceosomal Complex Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Generation Of Catalytic Spliceosome For First Transesterification Step Negative Regulation Of Potassium Ion Export Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Cis Assembly Of Pre-catalytic Spliceosome Regulation Of Heart Rate By Hormone Cellular Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Ion Transport Regulation Of Mitotic Cell Cycle	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Spliceosomal SnRNP Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Spliceosomal Tri-snRNP Complex Assembly Cellular Metabolic Process Negative Regulation Of Translation Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Translation Rhythmic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Metabolic Process MRNA Splice Site Selection Negative Regulation Of Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Metabolic Process Regulation Of RNA Stability Regulation Of Metabolic Process Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Histone H3-R2 Methylation 3'-UTR-mediated MRNA Destabilization Positive Regulation Of CAMP Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?