PRPF8 and HNRNPH2

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF8	HNRNPH2
Description		pre-mRNA processing factor 8	heterogeneous nuclear ribonucleoprotein H2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytosol Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Peptidase Activity U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding Metal-dependent Deubiquitinase Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor	Regulation Of RNA Splicing
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Calcium levels ( 20705733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		21 interacting genes: ABCA1 DHX9 DSCAM DUX4 ERG GPKOW H2BC5 HNRNPH2 NEDD4 PIN1 PTEN RNF20 SERPINB2 SLC22A2 SND1 SUMO2 TP53 UBC UBE2I USP7 ZNF830	97 interacting genes: CCNK DDX5 FXR1 HNRNPA0 HNRNPUL1 HSF2BP ILF3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MSI1 MSI2 OGT PQBP1 PRMT6 PRPF31 PRPF8 QKI RACK1 RAD21 RBFOX2 RBM10 RBM4 SF1 SNRPC SUMO2 TEKT1 TLE5 WDR83 WEE2-AS1
Entrez ID		10594	3188
HPRD ID		06295	03022
Ensembl ID		ENSG00000174231	ENSG00000126945
Uniprot IDs		Q6P2Q9	A0A384MDT2 P55795
PDB IDs		3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6S8Q 6S9I 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS2 7PJH 7PX3 7QTT 7W59 7W5A 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD	1WEZ 1WG5 6DG1 8SGH
Enriched GO Terms of Interacting Partners?		Postsynaptic Cytosol PML Body Nucleoplasm Phosphothreonine Residue Binding Macromolecule Metabolic Process Rhythmic Process Nucleus RISC Complex Binding Phosphoserine Residue Binding MRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Modification Process Ubiquitin Ligase Activator Activity P53 Binding Regulation Of Telomere Capping Protein Tag Activity Protein Modification By Small Protein Conjugation RNA Polymerase Binding Synapse Organization Protein Stabilization Regulation Of Cell Cycle Process Regulation Of Cell Cycle SUMO Transferase Activity RNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Circadian Behavior Rhythmic Behavior Regulation Of Telomere Maintenance Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Presynaptic Cytosol Osteoblast Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Binding Regulation Of Phosphorus Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Viral Process Central Nervous System Development Sphingolipid Floppase Activity 3'-5' DNA/RNA Helicase Activity Nuclear Body DNA-templated Viral Transcription Negative Regulation Of Catabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process MRNA Destabilization Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Motility
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