PRPF8 and SLC22A2

Number of citations of the paper that reports this interaction (PubMedID 31318583)
0

Data Source:
BioGRID (protein complementation assay)

		PRPF8	SLC22A2
Description		pre-mRNA processing factor 8	solute carrier family 22 member 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extracellular Exosome Presynapse
	Molecular Function	RNA Binding Protein Binding Peptidase Activity U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding Metal-dependent Deubiquitinase Activity	Amine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor	Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Body Fluid Secretion Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Amine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Choline Transport Dopamine Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Histamine Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Purine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport Spermidine Transmembrane Transport L-arginine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Calcium levels ( 20705733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)	A body shape index ( 34021172) Body mass index ( 25673413 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 20383146 31152163) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31451708 31152163 31015462 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hip circumference adjusted for BMI ( 34021172) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: ABCA1 DHX9 DSCAM DUX4 ERG GPKOW H2BC5 HNRNPH2 NEDD4 PIN1 PTEN RNF20 SERPINB2 SLC22A2 SND1 SUMO2 TP53 UBC UBE2I USP7 ZNF830	45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SNCA SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1
Entrez ID		10594	6582
HPRD ID		06295	04008
Ensembl ID		ENSG00000174231	ENSG00000112499
Uniprot IDs		Q6P2Q9	O15244
PDB IDs		3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6S8Q 6S9I 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS2 7PJH 7PX3 7QTT 7W59 7W5A 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD	8ET9
Enriched GO Terms of Interacting Partners?		Postsynaptic Cytosol PML Body Nucleoplasm Phosphothreonine Residue Binding Macromolecule Metabolic Process Rhythmic Process Nucleus RISC Complex Binding Phosphoserine Residue Binding MRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Modification Process Ubiquitin Ligase Activator Activity P53 Binding Regulation Of Telomere Capping Protein Tag Activity Protein Modification By Small Protein Conjugation RNA Polymerase Binding Synapse Organization Protein Stabilization Regulation Of Cell Cycle Process Regulation Of Cell Cycle SUMO Transferase Activity RNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Circadian Behavior Rhythmic Behavior Regulation Of Telomere Maintenance Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Presynaptic Cytosol Osteoblast Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Binding Regulation Of Phosphorus Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Viral Process Central Nervous System Development Sphingolipid Floppase Activity 3'-5' DNA/RNA Helicase Activity Nuclear Body DNA-templated Viral Transcription Negative Regulation Of Catabolic Process	Membrane Endoplasmic Reticulum Oligosaccharyltransferase Complex Regulation Of Lysosomal Membrane Permeability Endoplasmic Reticulum Membrane Multivesicular Body, Internal Vesicle Response To Peptide
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