PRPF8 and GPKOW

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PRPF8	GPKOW
Description		pre-mRNA processing factor 8	G-patch domain and KOW motifs
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex
	Molecular Function	RNA Binding Protein Binding Peptidase Activity U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding Metal-dependent Deubiquitinase Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Calcium levels ( 20705733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		21 interacting genes: ABCA1 DHX9 DSCAM DUX4 ERG GPKOW H2BC5 HNRNPH2 NEDD4 PIN1 PTEN RNF20 SERPINB2 SLC22A2 SND1 SUMO2 TP53 UBC UBE2I USP7 ZNF830	47 interacting genes: APP ARMCX1 BUD13 CCDC57 CNKSR3 DDIT4L EFHC2 FBXO7 GMPPA GOLGA2 GSTM5 HOOK2 HSF2BP IKBKG KANK2 LNX1 LRP2BP LZTS1 MAD1L1 MEOX2 MESD MID2 MTUS2 NINL OGT PHF1 PIBF1 PICK1 POLR2G PPP1CA PRKAR1B PRPF4 PRPF8 REL ROPN1 SH3GL1 SORBS3 SPDYE4 TCEA1 TCEA2 TRAF2 TRIM23 TRIM27 VPS52 WDR77 WDR83 ZMYND12
Entrez ID		10594	27238
HPRD ID		06295	06737
Ensembl ID		ENSG00000174231	ENSG00000068394
Uniprot IDs		Q6P2Q9	Q92917
PDB IDs		3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6S8Q 6S9I 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS2 7PJH 7PX3 7QTT 7W59 7W5A 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD	7DVQ 7QTT 8CH6
Enriched GO Terms of Interacting Partners?		Postsynaptic Cytosol PML Body Nucleoplasm Phosphothreonine Residue Binding Macromolecule Metabolic Process Rhythmic Process Nucleus RISC Complex Binding Phosphoserine Residue Binding MRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Modification Process Ubiquitin Ligase Activator Activity P53 Binding Regulation Of Telomere Capping Protein Tag Activity Protein Modification By Small Protein Conjugation RNA Polymerase Binding Synapse Organization Protein Stabilization Regulation Of Cell Cycle Process Regulation Of Cell Cycle SUMO Transferase Activity RNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Circadian Behavior Rhythmic Behavior Regulation Of Telomere Maintenance Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Presynaptic Cytosol Osteoblast Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Binding Regulation Of Phosphorus Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Viral Process Central Nervous System Development Sphingolipid Floppase Activity 3'-5' DNA/RNA Helicase Activity Nuclear Body DNA-templated Viral Transcription Negative Regulation Of Catabolic Process	Cytoplasm Protein Binding Identical Protein Binding Regulation Of Autophagy Positive Regulation Of Autophagy
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