PRPF8 and GPKOW

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PRPF8	GPKOW
Gene Name		pre-mRNA processing factor 8	G patch domain and KOW motifs
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm U5 SnRNP Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Nucleoplasm
	Molecular Function	Protein Binding U6 SnRNA Binding U5 SnRNA Binding Poly(A) RNA Binding K63-linked Polyubiquitin Binding	Molecular_function Nucleic Acid Binding Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression	Biological_process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		14 interactors: ABCA1 DHX9 EFTUD2 ERG GPKOW HNRNPH2 NEDD4 PIN1 PRPF19 SERPINB2 SND1 SNRNP200 UBC ZNF830	16 interactors: APP BUD13 CCDC57 GOLGA2 NINL PPP1CA PRPF4 PRPF8 ROPN1 SH3GL1 TCEA2 TERF2IP TRAF2 TRIM23 WDR77 WDR83
Entrez ID		10594	27238
HPRD ID		06295	06737
Ensembl ID		ENSG00000174231
Uniprot IDs		Q6P2Q9	Q92917
PDB IDs		3E9L 3ENB 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of Type I Interferon Production Negative Regulation Of Cellular Response To Growth Factor Stimulus Osteoblast Differentiation DNA Damage Checkpoint Blastocyst Growth Protein Polyubiquitination RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transport Response To Stress Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Type I Interferon Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ossification Cellular Nitrogen Compound Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Potassium Ion Transport Spliceosomal Complex Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Generation Of Catalytic Spliceosome For First Transesterification Step Negative Regulation Of Potassium Ion Export Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Cis Assembly Of Pre-catalytic Spliceosome Regulation Of Heart Rate By Hormone Cellular Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Ion Transport Regulation Of Mitotic Cell Cycle	MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing RNA Splicing Regulation Of Protein Binding RNA Metabolic Process Gene Expression Spliceosomal SnRNP Assembly Regulation Of Binding Negative Regulation Of DNA Recombination At Telomere Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Synaptic Growth At Neuromuscular Junction Nucleobase-containing Compound Metabolic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of NF-kappaB Transcription Factor Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Peptidase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Protein Localization To Chromosome, Telomeric Region Axon Choice Point Recognition Negative Regulation Of Glial Cell Apoptotic Process
Tagcloud ?		abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?