OXT and OXTR

Number of citations of the paper that reports this interaction (PubMedID 10698266)
0

Data Source:
HPRD (in vitro)

		OXT	OXTR
Description		oxytocin/neurophysin I prepropeptide	oxytocin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Terminal Bouton Neuronal Dense Core Vesicle	Plasma Membrane Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding Oxytocin Receptor Binding	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity
	Biological Process	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Genistein Response To Prostaglandin E Social Behavior Intracellular Signal Transduction Negative Regulation Of Urine Volume Response To Cocaine Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Response To Steroid Hormone Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Systemic Arterial Blood Pressure By Vasopressin System Process Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Female Pregnancy Lactation Cellular Response To Hormone Stimulus Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Maternal Process Involved In Parturition Regulation Of Biological Quality Positive Regulation Of Cold-induced Thermogenesis
Pathways		Vasopressin-like receptors G alpha (q) signalling events	Vasopressin-like receptors G alpha (q) signalling events
Drugs			Vasopressin Oxytocin Carbetocin Atosiban Relcovaptan
Diseases
GWAS		Blood protein levels ( 30072576) Serum oxytocin levels ( 31361301)	Caudate activity during reward ( 28927378) Chronotype ( 30696823) Depression and alcohol dependence ( 22064162) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598) Morning person ( 30696823)
Interacting Genes		5 interacting genes: ESR2 KMT2A OXTR PREP TXNDC17	18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3
Entrez ID		5020	5021
HPRD ID		08880	01328
Ensembl ID		ENSG00000101405	ENSG00000180914
Uniprot IDs		P01178 X5D7M6	B2R9L7 P30559
PDB IDs		7OFG 7OTD 7QVM 7RYC	6TPK 7QVM 7RYC
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Maternal Process Involved In Parturition Vasopressin Receptor Activity Oxytocin Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Vasopressin Oligopeptidase Activity Protein-disulfide Reductase [NAD(P)H] Activity Estrogen Response Element Binding	Neurohypophyseal Hormone Activity Maternal Aggressive Behavior Regulation Of Female Receptivity Female Mating Behavior Aggressive Behavior Maternal Behavior Grooming Behavior Parental Behavior Receptor Catabolic Process Mating Behavior Neuronal Dense Core Vesicle Positive Regulation Of Fatty Acid Biosynthetic Process Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Response To Electrical Stimulus Reproductive Behavior V1B Vasopressin Receptor Binding Positive Regulation Of Fatty Acid Metabolic Process Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding Receptor Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Tarsal Gland Development Uterine Gland Development
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