OXT and OXTR

Number of citations of the paper that reports this interaction (PMID 10698266)
0

Data Source:
HPRD (in vitro)

		OXT	OXTR
Gene Name		oxytocin/neurophysin I prepropeptide	oxytocin receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Terminal Bouton	Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Adherens Junction Apical Plasma Membrane
	Molecular Function	Neurohypophyseal Hormone Activity Oxytocin Receptor Binding	Oxytocin Receptor Activity Vasopressin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Sleep Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Prostaglandin E Social Behavior Negative Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Cocaine Hyperosmotic Salinity Response Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Uterine Smooth Muscle Contraction	Suckling Behavior Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Muscle Contraction Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Lactation Memory Positive Regulation Of Norepinephrine Secretion Telencephalon Development Sleep Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Response To Anoxia Response To Cytokine Social Behavior Response To Cocaine Response To Drug Maternal Behavior Sperm Ejaculation Eating Behavior Response To Peptide Hormone Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Digestive Tract Development Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Parturition Positive Regulation Of Penile Erection Negative Regulation Of Gastric Acid Secretion ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Response To Peptide
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Oxytocin	Oxytocin Carbetocin
Diseases
GWAS			Depression and alcohol dependence ( 22064162)
Protein-Protein Interactions		5 interactors: ESR2 KMT2A OXTR PREP TXNDC17	4 interactors: ARRB2 AVP GPRASP1 OXT
Entrez ID		5020	5021
HPRD ID		08880	01328
Ensembl ID		ENSG00000101405	ENSG00000180914
Uniprot IDs		P01178	B2R9L7 P30559
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Response To Drug Response To Anoxia Positive Regulation Of Norepinephrine Secretion Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Negative Regulation Of Gastric Acid Secretion Regulation Of Response To Drug Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Gastric Acid Secretion Regulation Of Systemic Arterial Blood Pressure By Vasopressin Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Penile Erection Sperm Ejaculation Maternal Process Involved In Parturition Rhythmic Process Regulation Of Penile Erection Positive Regulation Of Catecholamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Histone H3-K4 Trimethylation Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Synaptic Transmission, GABAergic Sleep Maternal Behavior Histone H4-K16 Acetylation Vagina Development Positive Regulation Of Histone H3-K4 Methylation Insemination Uterus Development ERK1 And ERK2 Cascade Parturition Intracellular Estrogen Receptor Signaling Pathway Epithelial Cell Differentiation Involved In Prostate Gland Development Response To Steroid Hormone Extracellular Negative Regulation Of Signal Transduction Gland Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Organic Substance Copulation Epithelial Cell Maturation Suckling Behavior Positive Regulation Of Synaptic Transmission, Glutamatergic Female Genitalia Development Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Negative Regulation Of Receptor Activity Positive Regulation Of Smooth Muscle Contraction Cellular Response To Hormone Stimulus Peptidyl-lysine Trimethylation	Maternal Aggressive Behavior Hyperosmotic Salinity Response Aggressive Behavior Positive Regulation Of Ion Transport Regulation Of Female Receptivity Maternal Behavior Negative Regulation Of Release Of Cytochrome C From Mitochondria Female Mating Behavior Grooming Behavior Regulation Of Renal Sodium Excretion Copulation Hyperosmotic Response Regulation Of Excretion Negative Regulation Of Mitochondrion Organization Mating Behavior Response To Salt Stress Positive Regulation Of Blood Pressure Social Behavior Single-organism Behavior Mating Regulation Of Neurological System Process Regulation Of Body Fluid Levels Positive Regulation Of Peptidyl-serine Phosphorylation Behavior Receptor Metabolic Process Regulation Of Ion Transport Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Response To Osmotic Stress Regulation Of Mitochondrion Organization Renal System Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Transport Positive Regulation Of Synaptic Transmission Multicellular Organismal Reproductive Process Positive Regulation Of Hindgut Contraction Multicellular Organism Reproduction Regulation Of Anion Transport Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Hindgut Contraction Reproduction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis
Tagcloud ?		altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip islets karger locomotor medulla nasal nts oxytocin paraventricular postrema potentiated pvn route solitary tolerance vagus	accumbens amygdaloid asds autism autistic autoradiography c57bl6 calls circuitry circuits compensative impairments interests intranasal mor mors motivation operates opioidergic opioids oprm1 oxytocin oxytocinergic physiopathology reward social socially ultrasonic
Tagcloud (Difference) ?		altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip islets karger locomotor medulla nasal nts paraventricular postrema potentiated pvn route solitary tolerance vagus	accumbens amygdaloid asds autism autistic autoradiography c57bl6 calls circuitry circuits compensative impairments interests intranasal mor mors motivation operates opioidergic opioids oprm1 oxytocinergic physiopathology reward social socially ultrasonic
Tagcloud (Intersection) ?		oxytocin