OXT and PREP

Number of citations of the paper that reports this interaction (PubMedID 12173)
0

Data Source:
HPRD (in vitro)

		OXT	PREP
Description		oxytocin/neurophysin I prepropeptide	prolyl endopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Terminal Bouton Neuronal Dense Core Vesicle	Extracellular Region Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding Oxytocin Receptor Binding	Metallocarboxypeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Oligopeptidase Activity
	Biological Process	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Genistein Response To Prostaglandin E Social Behavior Intracellular Signal Transduction Negative Regulation Of Urine Volume Response To Cocaine Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Response To Steroid Hormone Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis	Angiotensin Maturation Proteolysis
Pathways		Vasopressin-like receptors G alpha (q) signalling events
Drugs			1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Blood protein levels ( 30072576) Serum oxytocin levels ( 31361301)	Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: ESR2 KMT2A OXTR PREP TXNDC17	7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1
Entrez ID		5020	5550
HPRD ID		08880	02673
Ensembl ID		ENSG00000101405	ENSG00000085377
Uniprot IDs		P01178 X5D7M6	B2RAH7 P48147
PDB IDs		7OFG 7OTD 7QVM 7RYC	3DDU
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Maternal Process Involved In Parturition Vasopressin Receptor Activity Oxytocin Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Vasopressin Oligopeptidase Activity Protein-disulfide Reductase [NAD(P)H] Activity Estrogen Response Element Binding	Positive Regulation Of Cellular Component Biogenesis Blood Vessel Diameter Maintenance Hormone Activity Regulation Of Reactive Oxygen Species Metabolic Process Receptor Ligand Activity Regulation Of Tube Size Regulation Of Lipid Transport Extracellular Region Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission Positive Regulation Of Inflammatory Response Regulation Of Blood Pressure Neuronal Dense Core Vesicle Regulation Of Secretion By Cell Cell Killing Regulation Of Heart Contraction Regulation Of Secretion Neuropeptide Hormone Activity Regulation Of Biological Quality Cysteine-type Endopeptidase Inhibitor Activity Extracellular Space System Process Regulation Of Blood Circulation Regulation Of Catecholamine Secretion Terminal Bouton Regulation Of Cell Junction Assembly Vascular Process In Circulatory System Regulation Of Microtubule-based Process Humoral Immune Response Response To Cocaine Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Pressure Positive Regulation Of Secretion By Cell Positive Regulation Of Cell Communication Positive Regulation Of Signaling Circulatory System Process Axon Terminus Positive Regulation Of Secretion Positive Regulation Of Ossification Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding
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