NAA50 and BHLHE40

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAA50	BHLHE40
Description		N-alpha-acetyltransferase 50, NatE catalytic subunit	basic helix-loop-helix family member e40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol NatA Complex Extracellular Exosome	Chromatin Nucleus Cytoplasm Nuclear Body
	Molecular Function	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein-lysine-acetyltransferase Activity Protein N-terminal-methionine Acetyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Remodeling N-terminal Protein Amino Acid Acetylation Mitotic Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Post-translational Protein Modification Mitotic Sister Chromatid Cohesion, Centromeric	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis
Pathways			BMAL1:CLOCK,NPAS2 activates circadian expression Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Cognitive function in longevity ( 33607172) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Serum alkaline phosphatase levels ( 33547301) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		6 interacting genes: BHLHE40 CEBPA JMJD6 NAA10 NAA15 OTX2	91 interacting genes: AAMP AANAT APH1A ATXN1 BHLHE41 BMAL1 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MTCL2 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM11 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOX15 STAT3 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WHR1 WT1 ZFHX3 ZHX1
Entrez ID		80218	8553
HPRD ID		14350	16050
Ensembl ID		ENSG00000121579	ENSG00000134107
Uniprot IDs		E7EQ69 Q9GZZ1	O14503 Q6IB83
PDB IDs		2OB0 2PSW 3TFY 4X5K 6PPL 6PW9 6WF3 6WF5 6WFG 6WFK 6WFN 6WFO 9F1B 9F1C 9F1D
Enriched GO Terms of Interacting Partners?		NatA Complex Lung Development N-terminal Protein Amino Acid Acetylation Acetyltransferase Activity Protein Acetylation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Ribosome Binding Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Response To Vitamin B2 C/EBP Complex Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity CHOP-C/EBP Complex Protein N-terminal-serine Acetyltransferase Activity Negative Regulation Of Protein Homooligomerization Ciliary Inversin Compartment White Fat Cell Proliferation Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Maintenance Of Animal Organ Identity DNA-binding Transcription Factor Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion MRF Binding Kidney Development Determination Of Pancreatic Left/right Asymmetry Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein-N-terminal Amino-acid Acetyltransferase Activity Recognition Of Apoptotic Cell Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Response To Phenylpropanoid Regulation Of RNA Biosynthetic Process Fat Cell Proliferation Eukaryotic Initiation Factor 4E Binding Anatomical Structure Formation Involved In Morphogenesis	Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Myoblast Differentiation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Rhythmic Process Cytoplasmic Stress Granule Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process E-box Binding Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Circadian Rhythm Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Remodeling DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of RNA Splicing Mitogen-activated Protein Kinase Kinase Kinase Binding
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