FOXA2 and EN2

Number of citations: 0 (PubMedID 12642491)
Data Source: BioGRID (pull down), HPRD (in vitro)

		FOXA2	EN2
Name		forkhead box A2	engrailed homeobox 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Positive Regulation Of Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Dopaminergic Neuron Differentiation Embryonic Brain Development
Pathways		Regulation of gene expression in beta cells Positive Regulation of CDH1 Gene Transcription Formation of axial mesoderm Formation of definitive endoderm Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	None
Drugs		None	N-cyclohexyltaurine
GWAS		Adolescent idiopathic scoliosis ( 25784220 ) Apolipoprotein A1 levels ( 32203549 ) Birth weight ( 31043758 ) Body size at age 10 ( 32376654 ) Fasting blood glucose ( 22581228 33842983 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting glucose ( 34059833 ) Fasting plasma glucose ( 20152958 25187374 ) Gout ( 22179738 ) Hypothyroidism ( 27182965 ) Male-pattern baldness ( 27182965 22693459 ) Monobrow ( 27182965 ) Type 2 diabetes ( 30054458 32499647 ) Vitamin D levels ( 26704534 )	Cytomegalovirus pp28 antibody levels ( 33204752 ) HDL cholesterol levels in HIV infection ( 33109212 ) Metabolite levels ( 23823483 )
Interacting Genes		10 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTUD3 OTX2 TLE1	2 interacting genes: EIF4E FOXA2
Entrez ID		3170	2020
HPRD ID		02618	08836
Ensembl ID		ENSG00000125798	ENSG00000164778
Uniprot IDs		B0ZTD4 Q9Y261	P19622
PDB IDs		5X07 7YZE 7YZF	Not available
GO Terms Enriched among Interactors		Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gastrulation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Primitive Streak Formation Regulation Of Gastrulation Neuron Differentiation DNA Binding Animal Organ Development Positive Regulation Of Embryonic Development Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Midbrain Development Dopaminergic Neuron Differentiation Endoderm Development Animal Organ Morphogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Gastrulation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cerebellum Development Regionalization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Tissue Development Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Dorsal Spinal Cord Interneuron Posterior Axon Guidance Nephric Duct Elongation Ectoderm Formation Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose	Eukaryotic Initiation Factor 4G Binding Neuron Differentiation MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse RNA Cap Binding RNA 7-methylguanosine Cap Binding Chromatoid Body Negative Regulation Of Cell Differentiation Eukaryotic Translation Initiation Factor 4F Complex Primitive Streak Formation Positive Regulation Of Gastrulation Regulation Of Gastrulation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Endocrine Pancreas Development Positive Regulation Of Embryonic Development Response To Interleukin-6 Negative Regulation Of Developmental Process Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Dopaminergic Neuron Differentiation Fear Response Response To Dexamethasone Negative Regulation Of Epithelial To Mesenchymal Transition Translation Initiation Factor Activity RNA Export From Nucleus Cell Cycle G1/S Phase Transition Cellular Response To Steroid Hormone Stimulus G1/S Transition Of Mitotic Cell Cycle Cytoplasmic Ribonucleoprotein Granule Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus MRNA Export From Nucleus Multicellular Organismal Response To Stress Translational Initiation Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Adult Locomotory Behavior Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Embryonic Development Cell Fate Specification RISC Complex Cytoplasmic Stress Granule