OSBP and VAPB

Number of citations of the paper that reports this interaction (PubMedID 39119292)
48

Data Source:
BioGRID (protein complementation assay)

		OSBP	VAPB
Description		oxysterol binding protein	VAMP associated protein B and C
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Endoplasmic Reticulum Exit Site Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Oxysterol Binding Lipid Binding Protein Domain Specific Binding Sterol Binding Phosphatidylinositol-4-phosphate Binding Lipid Transfer Activity Sterol Transfer Activity	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding
	Biological Process	Sphingomyelin Biosynthetic Process Bile Acid Biosynthetic Process Lipid Transport Phospholipid Transport Sterol Transport Intracellular Cholesterol Transport Ceramide Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer Positive Regulation Of Secretory Granule Organization	Intracellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Endoplasmic Reticulum Organization Viral Release From Host Cell Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Suppression Of Viral Release By Host Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization
Pathways		Sphingolipid de novo biosynthesis Synthesis of bile acids and bile salts	Sphingolipid de novo biosynthesis RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle
Drugs
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Interacting Genes		4 interacting genes: CSNK2A1 SNAP25 VAPA VAPB	49 interacting genes: AIG1 AQP2 AQP6 BIK CD79A CFTR CYB561 CYBRD1 EBAG9 EBP ELOVL4 FAM174A GJA8 GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MAILR MTNR1A OSBP OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC10A1 SLC18A1 SLC22A1 SQSTM1 STARD3 STX1A STX2 STX4 STX5 TIMMDC1 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15
Entrez ID		5007	9217
HPRD ID		01327	09300
Ensembl ID		ENSG00000110048	ENSG00000124164
Uniprot IDs		P22059	O95292 Q53XM7
PDB IDs		2RR3 7V62	2MDK 3IKK
Enriched GO Terms of Interacting Partners?		FFAT Motif Binding COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization By Membrane Tethering Membrane Docking Endoplasmic Reticulum Localization Organelle Localization Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Viral Release From Host Cell Endoplasmic Reticulum Exit Site Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process Cadherin Binding Vesicle Organization Organelle Organization Endoplasmic Reticulum Organization Cholesterol Transport Host-mediated Perturbation Of Viral Process Sterol Transport Establishment Of Localization In Cell Host-mediated Perturbation Of Symbiont Process Modulation Of Process Of Another Organism Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation By Virus Of Viral Protein Levels In Host Cell Viral Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Membrane Fusion Biological Process Involved In Interaction With Host Organic Hydroxy Compound Transport Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Plasma Membrane Protein Folding Positive Regulation Of Aggrephagy Microtubule Bundle Ribbon Synapse Regulation Of Neurofibrillary Tangle Assembly Neuronal Dense Core Vesicle Exocytosis Host-mediated Perturbation Of Viral RNA Genome Replication Microtubule Binding Regulation Of Biological Quality Dense Core Granule Exocytosis Wnt Signaling Pathway	Membrane SNAP Receptor Activity SNARE Complex Organic Hydroxy Compound Transport Vesicle Docking SNARE Binding SNARE Complex Assembly Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle Organization Endoplasmic Reticulum Membrane Membrane Fusion Regulation Of Insulin Secretion Endomembrane System Regulation Of Hormone Secretion Membrane Organization Endoplasmic Reticulum Establishment Of Localization In Cell Regulation Of Hormone Levels Regulation Of Peptide Hormone Secretion Ascorbate Homeostasis Exocytosis Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cholesterol Transport Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Water Transport Transmembrane Transport Basolateral Plasma Membrane Sterol Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Exocytosis Regulation Of Protein Secretion Protein Binding Cytoplasmic Vesicle Cornified Envelope Assembly Norepinephrine Uptake Secretion By Cell Fluid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chloride Channel Inhibitor Activity Neurotransmitter Transport Positive Regulation Of Secretion By Cell Regulation Of Secretion By Cell
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