OSBP and VAPA

Number of citations of the paper that reports this interaction (PubMedID 12023275)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		OSBP	VAPA
Description		oxysterol binding protein	VAMP associated protein A
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum	Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Oxysterol Binding Lipid Binding Protein Domain Specific Binding Sterol Binding Phosphatidylinositol-4-phosphate Binding Lipid Transfer Activity Sterol Transfer Activity	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity
	Biological Process	Sphingomyelin Biosynthetic Process Bile Acid Biosynthetic Process Lipid Transport Phospholipid Transport Sterol Transport Intracellular Cholesterol Transport Ceramide Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer Positive Regulation Of Secretory Granule Organization	Sphingomyelin Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Phospholipid Transport Sterol Transport Viral Release From Host Cell Cholesterol Transport Neuron Projection Development Protein Folding In Endoplasmic Reticulum Ceramide Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Membrane Fusion Endoplasmic Reticulum-plasma Membrane Tethering Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		Sphingolipid de novo biosynthesis Synthesis of bile acids and bile salts	Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS			Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		4 interacting genes: CSNK2A1 SNAP25 VAPA VAPB	47 interacting genes: ADGRG7 ADRB2 APOD AQP6 BIK CACNG1 CD79A CFTR CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 KCNB2 LEPROTL1 NSF NXF1 OCIAD1 OPRM1 OSBP RB1CC1 RETREG3 RMDN2 RMDN3 SCN3B SEC11C SIK1 SLC16A7 SLC18A1 SLC35B1 SNX2 STARD3 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 USP40 VAMP1 VAMP2 ZBTB22
Entrez ID		5007	9218
HPRD ID		01327	09299
Ensembl ID		ENSG00000110048	ENSG00000101558
Uniprot IDs		P22059	Q9P0L0
PDB IDs		2RR3 7V62	2RR3 6TQR
Enriched GO Terms of Interacting Partners?		FFAT Motif Binding COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization By Membrane Tethering Membrane Docking Endoplasmic Reticulum Localization Organelle Localization Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Viral Release From Host Cell Endoplasmic Reticulum Exit Site Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process Cadherin Binding Vesicle Organization Organelle Organization Endoplasmic Reticulum Organization Cholesterol Transport Host-mediated Perturbation Of Viral Process Sterol Transport Establishment Of Localization In Cell Host-mediated Perturbation Of Symbiont Process Modulation Of Process Of Another Organism Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation By Virus Of Viral Protein Levels In Host Cell Viral Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Membrane Fusion Biological Process Involved In Interaction With Host Organic Hydroxy Compound Transport Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Plasma Membrane Protein Folding Positive Regulation Of Aggrephagy Microtubule Bundle Ribbon Synapse Regulation Of Neurofibrillary Tangle Assembly Neuronal Dense Core Vesicle Exocytosis Host-mediated Perturbation Of Viral RNA Genome Replication Microtubule Binding Regulation Of Biological Quality Dense Core Granule Exocytosis Wnt Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Ascorbate Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Localization To Cell Periphery Transmembrane Monodehydroascorbate Reductase Activity Regulation Of Cellular Localization Organic Hydroxy Compound Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Establishment Of Protein Localization Cellular Localization Endosome Establishment Of Localization In Cell Regulation Of Protein Localization Regulation Of Protein Transport Transmembrane Transport Monoatomic Ion Transport Protein Localization To Membrane Protein Localization To Plasma Membrane ERBB2-EGFR Signaling Pathway Potassium Channel Regulator Activity Negative Regulation Of Protein Transport Syntaxin Binding Monoatomic Ion Channel Complex Organelle Membrane Contact Site Cytoplasmic Vesicle SNARE Complex Assembly Inorganic Ion Transmembrane Transport Localization Within Membrane Negative Regulation Of Establishment Of Protein Localization Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hormone Secretion Regulation Of Protein Secretion SNARE Binding Regulation Of Transport Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Cholesterol Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Endosome Membrane Metal Ion Transport Negative Regulation Of Protein Secretion Syntaxin-1 Binding Protein Binding Regulation Of Insulin Secretion Inorganic Cation Transmembrane Transport
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