NVL and CRMP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NVL	CRMP1
Gene Name		nuclear VCP-like	collapsin response mediator protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Plasma Membrane Membrane	Cytoplasm Microtubule Organizing Center Spindle Cytosol Dendrite Neuronal Cell Body
	Molecular Function	ATP Binding Poly(A) RNA Binding	Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process		Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance
Pathways			Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Major depressive disorder ( 21042317)	Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		4 interactors: CRMP1 OSGEP RPL5 TTF2	78 interactors: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LSM2 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1D1 ZAK ZNF24
Entrez ID		4931	1400
HPRD ID		03887	03913
Ensembl ID		ENSG00000143748	ENSG00000072832
Uniprot IDs		B4DF43 O15381	B3KT07 E9PD68 Q14194 Q96I11
PDB IDs		2X8A	4B3Z
Enriched GO Terms of Interacting Partners?		Threonylcarbamoyladenosine Biosynthetic Process Pharynx Development Threonylcarbamoyladenosine Metabolic Process Soft Palate Development Pyrimidine Nucleobase Catabolic Process Nucleobase-containing Compound Metabolic Process Hard Palate Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process NcRNA Metabolic Process Adenosine Metabolic Process MRNA Metabolic Process Nitrogen Compound Metabolic Process Thyroid Hormone Generation Ribosomal Large Subunit Biogenesis Nucleobase-containing Small Molecule Metabolic Process Thyroid Hormone Metabolic Process Thyroid Gland Development Hair Follicle Morphogenesis Pyrimidine Nucleobase Metabolic Process Termination Of RNA Polymerase II Transcription Epidermis Morphogenesis	Cell Death Death Developmental Process Apoptotic Process Programmed Cell Death Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Catabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cysteine-type Endopeptidase Activity Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance Protein Homooligomerization Response To Stress Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Cytoskeleton Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Cellular Process Stress-activated MAPK Cascade Nervous System Development Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity System Development Positive Regulation Of Catalytic Activity Postreplication Repair Regulation Of Cellular Component Organization Protein Oligomerization Cellular Macromolecule Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Complex Assembly Heterocycle Metabolic Process
Tagcloud ?		amyotrophic bioinformatics complementary converging destabilizing differently fate frontotemporal fus grn lobar localize motoneuron motoneuronal mrnas neurodegeneration nsc progranulin recognize ribonucleoprotein sets taf15 tdp ug ultimately utr utrs vegfa vps54	aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		amyotrophic bioinformatics complementary converging destabilizing differently fate frontotemporal fus grn lobar localize motoneuron motoneuronal mrnas neurodegeneration nsc progranulin recognize ribonucleoprotein sets taf15 tdp ug ultimately utr utrs vegfa vps54	aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?