NVL and RPL5

Number of citations of the paper that reports this interaction (PMID 15469983)
10

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NVL	RPL5
Gene Name		nuclear VCP-like	ribosomal protein L5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Plasma Membrane Membrane	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	ATP Binding Poly(A) RNA Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Poly(A) RNA Binding
	Biological Process		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Major depressive disorder ( 21042317)	Height ( 20881960) Multiple sclerosis ( 19525955 17660530)
Protein-Protein Interactions		4 interactors: CRMP1 OSGEP RPL5 TTF2	21 interactors: CSNK2A1 CSNK2B DCC EIF5A HARS IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL PDCD4 PPM1D SPP1 SURF2 TNIP1 TNPO1 TSC22D1 UPF2 VHL
Entrez ID		4931	6125
HPRD ID		03887	04699
Ensembl ID		ENSG00000143748	ENSG00000122406
Uniprot IDs		B4DF43 O15381	A2RUM7 B3KTM6 P46777
PDB IDs		2X8A	3J3B
Enriched GO Terms of Interacting Partners?		Threonylcarbamoyladenosine Biosynthetic Process Pharynx Development Threonylcarbamoyladenosine Metabolic Process Soft Palate Development Pyrimidine Nucleobase Catabolic Process Nucleobase-containing Compound Metabolic Process Hard Palate Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process NcRNA Metabolic Process Adenosine Metabolic Process MRNA Metabolic Process Nitrogen Compound Metabolic Process Thyroid Hormone Generation Ribosomal Large Subunit Biogenesis Nucleobase-containing Small Molecule Metabolic Process Thyroid Hormone Metabolic Process Thyroid Gland Development Hair Follicle Morphogenesis Pyrimidine Nucleobase Metabolic Process Termination Of RNA Polymerase II Transcription Epidermis Morphogenesis	Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Cytoplasmic Transport Protein Localization To Organelle Establishment Of Protein Localization To Organelle Negative Regulation Of Collateral Sprouting Ribosomal Protein Import Into Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Intracellular Protein Transport Cellular Protein Localization Viral Process Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Programmed Cell Death Intracellular Transport Cell Death Death Protein Import Into Nucleus, Translocation Cellular Localization Response To External Stimulus Protein Localization Protein Transport Establishment Of Localization In Cell Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Cellular Response To UV-C Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Vitamin B1 Negative Regulation Of Axonogenesis Chemotaxis MRNA Export From Nucleus Regulation Of MAPK Cascade Histidyl-tRNA Aminoacylation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury RNA Export From Nucleus Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Developmental Growth Spinal Cord Ventral Commissure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Growth Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?		amyotrophic bioinformatics complementary converging destabilizing differently fate frontotemporal fus grn lobar localize motoneuron motoneuronal mrnas neurodegeneration nsc progranulin recognize ribonucleoprotein sets taf15 tdp ug ultimately utr utrs vegfa vps54	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?		amyotrophic bioinformatics complementary converging destabilizing differently fate frontotemporal fus grn lobar localize motoneuron motoneuronal mrnas neurodegeneration nsc progranulin recognize ribonucleoprotein sets taf15 tdp ug ultimately utr utrs vegfa vps54	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?