NVL and ADARB1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		NVL	ADARB1
Description		nuclear VCP like	adenosine deaminase RNA specific B1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein-containing Complex Binding Preribosome Binding	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	RRNA Processing Positive Regulation Of Protein Binding Positive Regulation Of Telomere Maintenance Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Protein Localization To Nucleolus Telomerase Holoenzyme Complex Assembly	Immune System Process Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process
Pathways			C6 deamination of adenosine Formation of editosomes by ADAR proteins
Drugs
Diseases
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 21042317) Mean corpuscular hemoglobin ( 32888494)	Adult body size ( 32376654) Age at first birth ( 34211149) Body mass index ( 25673413 28892062) Gastroesophageal reflux disease ( 34187846) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mild obesity-related type 2 diabetes ( 34737425) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)
Interacting Genes		11 interacting genes: ADARB1 CRMP1 FBXO7 HSPB1 LINC00839 OSGEP RNF10 RNF4 RPL5 TTF2 UBE2I	63 interacting genes: APP DCN EDIL3 EHHADH EIF2AK2 LARP6 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF NVL PIN1 PNPT1 PRKRA RBFOX2 RSL1D1 SNRNP70 STAU1 STOX1 STRBP SURF6 TARBP2 TCEANC UBE2I USP7 ZMAT4 ZNF346
Entrez ID		4931	104
HPRD ID		03887	06777
Ensembl ID		ENSG00000143748	ENSG00000197381
Uniprot IDs		B4DF43 O15381	A0A994J4V7 A0A994J7T5 P78563
PDB IDs		2X8A 6RO1	1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF 7KFN 8E0F 8E4X 9D5J 9D5K
Enriched GO Terms of Interacting Partners?		Hypoglossal Nerve Morphogenesis Negative Regulation Of Protein Kinase C Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Cytoplasm Adenosine To Inosine Editing RNA Processing Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Cytosol Regulation Of Protein Kinase C Signaling Unfolded Protein Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Ubiquitin Binding Regulation Of Kinetochore Assembly Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Polymer Binding Protein K48-linked Ubiquitination PML Body Cytosolic Ribosome Negative Regulation Of Protein Neddylation RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Lewy Body Core EKC/KEOPS Complex TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity TRNA Threonylcarbamoyladenosine Modification TRNA-specific Adenosine Deaminase Activity Dihydropyrimidinase Activity Regulation Of Centromere Complex Assembly Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization To Chromatin	RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Vesicle Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration
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