PSMC4 and PSMD10

Number of citations of the paper that reports this interaction (PubMedID 11779854)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PSMC4	PSMD10
Description		proteasome 26S subunit, ATPase 4	proteasome 26S subunit, non-ATPase 10
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Ciliary Basal Body	Proteasome Complex Nucleus Cytoplasm Cytosol Cytoskeleton Cilium Proteasome Regulatory Particle, Base Subcomplex Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Blastocyst Development Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Cell Growth Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Regulatory Particle Assembly Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: CEBPA FILNC1 NPM1 NR1I3 OGT PAAF1 PSMC2 PSMC3 PSMC5 PSMD10 RNF2 RORB SUMO2 TRAP1 UBASH3A UBLCP1 ZFAND1	17 interacting genes: AGTR1 CCND2 CDK4 CEBPA CLIC1 GRSF1 HSPA4 LDB1 MAGEA4 MDM2 NCK2 NFKB1 PSAT1 PSMC4 RB1 RELA UBC
Entrez ID		5704	5716
HPRD ID		04085	04594
Ensembl ID		ENSG00000013275	ENSG00000101843
Uniprot IDs		A8K2M0 P43686	O75832
PDB IDs		2DVW 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	1QYM 1TR4 1UOH 4NIK 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 7VO6 7VXV 7VXW 7VY4 7VY7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Complex Proteasome-activating Activity Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Proteasome Accessory Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process ATP Hydrolysis Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Transcription Regulator Complex NF-kappaB P50/p65 Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Rb-E2F Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Cellular Response To Peptide Hormone Stimulus Cellular Response To Nicotine Regulation Of Inflammatory Response Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Cell Differentiation Response To Vitamin Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Initiation Regulation Of Cell Population Proliferation Actinin Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Population Proliferation Response To Interleukin-6 Positive Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone Response To Ether Response To Tumor Necrosis Factor Regulation Of Apoptotic Process Nucleoplasm Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Histone Deacetylase Binding
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