RBPJ and NOTCH2

Number of citations of the paper that reports this interaction (PubMedID 9032325)
70

Data Source:
HPRD (in vitro, in vivo)

		RBPJ	NOTCH2
Description		recombination signal binding protein for immunoglobulin kappa J region	notch receptor 2
Image
GO Annotations	Cellular Component	Chromatin MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Transcription Repressor Complex	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Transcription Coactivator Activity Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Somitogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Heart Development Cell Population Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Pituitary Gland Development Hemopoiesis Cell Differentiation Neuron Differentiation B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Animal Organ Development Sebaceous Gland Development Hair Follicle Maturation Artery Morphogenesis Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Ventricular Septum Morphogenesis Club Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Stem Cell Proliferation Blood Vessel Lumenization Positive Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Endothelial Cell Fate Specification Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Placenta Development Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Atrioventricular Node Development Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Humoral Immune Response Notch Signaling Pathway Determination Of Left/right Symmetry Nervous System Development Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Hemopoiesis Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Septum Morphogenesis Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Proximal Tubule Development Podocyte Development Glomerular Capillary Formation Hepatocyte Proliferation Liver Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of Hemopoiesis Cholangiocyte Proliferation Regulation Of Osteoclast Development
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm Somitogenesis	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases			Alagille syndrome Hajdu-Cheney syndrome Type II diabetes mellitus
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Autoimmune traits (pleiotropy) ( 30572963) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24449572) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Takayasu arteritis ( 33308445) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Hepatocyte growth factor levels ( 25998175) Nevus count or cutaneous melanoma ( 32341527) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34012112 34127860) Type 2 diabetes ( 18372903 30054458 30297969)
Interacting Genes		29 interacting genes: APP CCNF CIRSR FHL1 GADD45A GSK3B HDAC1 HMGB1 HSPB1 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A PTOV1 RPS6KA6 SIN3A SND1 SNW1 SPEN SPOP SUFU TP53	31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SHANK3 SMAD1
Entrez ID		3516	4853
HPRD ID		00920	02606
Ensembl ID		ENSG00000168214	ENSG00000134250
Uniprot IDs		Q06330	Q04721 Q6IQ50
PDB IDs		2F8X 3NBN 3V79 6PY8	2OO4 5MWB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Repressor Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Nucleoplasm Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Notch Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Transcription Coactivator Activity Histone Deacetylase Binding Regulation Of MiRNA Transcription Positive Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Notch Binding Regulation Of Primary Metabolic Process Atrioventricular Node Development Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Metabolic Process Positive Regulation Of Muscle Cell Differentiation Chromatin Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Developmental Process	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Notch Binding Mononuclear Cell Differentiation Regulation Of Cell Adhesion Lymphocyte Differentiation Leukocyte Differentiation Marginal Zone B Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Timing Of Cell Differentiation Positive Regulation Of Signaling Lymphocyte Activation Somitogenesis Regulation Of Development, Heterochronic Signal Transduction Segmentation O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Leukocyte Activation Cell Differentiation Pattern Specification Process MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transcription Coactivator Activity Immune System Process Endothelial Cell Fate Specification Compartment Pattern Specification Mature B Cell Differentiation Involved In Immune Response Cell Activation Myoblast Differentiation Regulation Of Cell Population Proliferation Mature B Cell Differentiation Loop Of Henle Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Animal Organ Morphogenesis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?