RBPJ and SND1

Number of citations of the paper that reports this interaction (PubMedID 7651391)
62

Data Source:
HPRD (in vitro, in vivo)

		RBPJ	SND1
Description		recombination signal binding protein for immunoglobulin kappa J region	staphylococcal nuclease and tudor domain containing 1
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GO Annotations	Cellular Component	Chromatin MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Transcription Repressor Complex	Nucleus Cytoplasm Cytosol Membrane RNAi Effector Complex Melanosome Extracellular Exosome Dense Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity Cadherin Binding RISC Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Somitogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Heart Development Cell Population Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Pituitary Gland Development Hemopoiesis Cell Differentiation Neuron Differentiation B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Animal Organ Development Sebaceous Gland Development Hair Follicle Maturation Artery Morphogenesis Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Ventricular Septum Morphogenesis Club Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Stem Cell Proliferation Blood Vessel Lumenization Positive Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Endothelial Cell Fate Specification Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Stem Cell Proliferation	Osteoblast Differentiation MRNA Catabolic Process Regulation Of Cell Cycle Process MiRNA Catabolic Process Regulatory NcRNA-mediated Gene Silencing
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm Somitogenesis	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Autoimmune traits (pleiotropy) ( 30572963) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24449572) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Takayasu arteritis ( 33308445) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Coffee consumption ( 31046077) Estimated glomerular filtration rate ( 31152163) Fruit consumption ( 32066663) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Hemoglobin A1c levels ( 29403010) Number of sexual partners ( 30643258) Offspring birth weight ( 31043758) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 23532257 32499647)
Interacting Genes		29 interacting genes: APP CCNF CIRSR FHL1 GADD45A GSK3B HDAC1 HMGB1 HSPB1 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A PTOV1 RPS6KA6 SIN3A SND1 SNW1 SPEN SPOP SUFU TP53	28 interacting genes: APP CEBPA CREBBP CSNK2A1 ESR1 GTF2E1 GTF2E2 HOXA1 LINC00624 LZTR1 MAK MYB MYBL2 PDE4B PIM1 POLR2A PRPF8 PTGER4 RBPJ RNF10 RNU1-1 RNU2-1 RNU4-1 RNU5A-1 RNU6-1 STAT6 SUMO2 UBE2I
Entrez ID		3516	27044
HPRD ID		00920	03714
Ensembl ID		ENSG00000168214	ENSG00000197157
Uniprot IDs		Q06330	A0A140VK49 Q7KZF4
PDB IDs		2F8X 3NBN 3V79 6PY8	2E6N 2HQE 2HQX 2O4X 3BDL 3OMC 3OMG 4QMG 5M9O 7KNW 7KNX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Repressor Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Nucleoplasm Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Notch Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Transcription Coactivator Activity Histone Deacetylase Binding Regulation Of MiRNA Transcription Positive Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Notch Binding Regulation Of Primary Metabolic Process Atrioventricular Node Development Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Metabolic Process Positive Regulation Of Muscle Cell Differentiation Chromatin Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Developmental Process	Formation Of Quadruple SL/U4/U5/U6 SnRNP Spliceosomal Tri-snRNP Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Assembly Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Factor TFIIE Complex Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Cellular Component Assembly Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Binding Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Cell Activation Involved In Immune Response U6 SnRNA Binding Response To Cytokine Response To Peptide Protein-containing Complex Organization DNA Binding Regulation Of MiRNA Transcription Mammary Gland Epithelial Cell Proliferation Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Catabolic Process Regulation Of Stem Cell Proliferation Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Factor Binding SUMO Transferase Activity U5 SnRNP Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Cellular Response To Cytokine Stimulus
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