RBPJ and ZCCHC4

Data Source: HiPPIP (Novel)

		RBPJ	ZCCHC4
Name		recombination signal binding protein for immunoglobulin kappa J region	zinc finger CCHC-type containing 4
Structure
GO Annotations	Cellular Component	Chromatin MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Transcription Repressor Complex	Nucleus Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Nucleic Acid Binding Methyltransferase Activity Zinc Ion Binding RRNA (adenine-N6-)-methyltransferase Activity Transferase Activity Metal Ion Binding S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Somitogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Heart Development Cell Population Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Pituitary Gland Development Hemopoiesis Cell Differentiation Neuron Differentiation B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Animal Organ Development Sebaceous Gland Development Hair Follicle Maturation Artery Morphogenesis Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Ventricular Septum Morphogenesis Club Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Stem Cell Proliferation Blood Vessel Lumenization Positive Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Endothelial Cell Fate Specification Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Stem Cell Proliferation	RRNA Methylation Methylation Positive Regulation Of Translation
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm Somitogenesis	None
GWAS		A body shape index ( 34021172 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Autoimmune traits (pleiotropy) ( 30572963 ) Heel bone mineral density ( 30598549 ) Medication use (thyroid preparations) ( 31015401 ) Monocyte percentage of white cells ( 32888494 ) Rheumatoid arthritis ( 23143596 24449572 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Takayasu arteritis ( 33308445 ) Triglyceride levels ( 32203549 32154731 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Logical memory (immediate recall) in normal cognition ( 29274321 ) Multisite chronic pain ( 33830993 )
Novel Interactors		8 novel interactors: ART3 CCKAR INSL3 RSC1A1 SEL1L3 SPTB ZCCHC4 ZDHHC7	2 novel interactors: RBPJ SLIT2
Interacting Genes		29 interacting genes: APP CCNF CIRSR FHL1 GADD45A GSK3B HDAC1 HMGB1 HSPB1 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A PTOV1 RPS6KA6 SIN3A SND1 SNW1 SPEN SPOP SUFU TP53	None recorded
Entrez ID		3516	29063
HPRD ID		00920	15702
Ensembl ID		ENSG00000168214	ENSG00000168228
Uniprot IDs		Q06330	Q9H5U6
PDB IDs		2F8X 3NBN 3V79 6PY8	6UCA
GO Terms Enriched among Interactors		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Repressor Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Nucleoplasm Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Notch Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Transcription Coactivator Activity Histone Deacetylase Binding Regulation Of MiRNA Transcription Positive Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Notch Binding Regulation Of Primary Metabolic Process Atrioventricular Node Development Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Metabolic Process Positive Regulation Of Muscle Cell Differentiation Chromatin Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Developmental Process	Ventricular Septum Morphogenesis Cardiac Septum Morphogenesis Epithelial Tube Morphogenesis Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord MAML1-RBP-Jkappa- ICN1 Complex Tube Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Club Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Pulmonary Valve Development Morphogenesis Of An Epithelium Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Endocardium Development Endothelial Cell Fate Specification Tissue Morphogenesis Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Response To Heparin Regulation Of Negative Chemotaxis Cellular Response To Heparin Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Neutrophil Chemotaxis Roundabout Signaling Pathway Negative Regulation Of Smooth Muscle Cell Chemotaxis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Aortic Valve Development Hair Follicle Maturation Semi-lunar Valve Development Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Neutrophil Migration Roundabout Binding Positive Regulation Of Transcription Of Notch Receptor Target Response To Cortisol Laminin-1 Binding Negative Regulation Of Monocyte Chemotaxis Sebaceous Gland Development Dorsal Aorta Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Growth Cardiac Muscle Cell Myoblast Differentiation Endothelial Tube Morphogenesis