DLL1 and NOTCH3

Number of citations of the paper that reports this interaction (PMID 12482954)
19

Data Source:
HPRD (in vitro, in vivo)

		DLL1	NOTCH3
Gene Name		delta-like 1 (Drosophila)	notch 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle	Golgi Membrane Extracellular Region Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding	Calcium Ion Binding Protein Binding Enzyme Binding
	Biological Process	Cell Fate Determination Somite Specification Heart Looping Notch Signaling Pathway Notch Receptor Processing Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Hemopoiesis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Interleukin-10 Production Negative Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development Left/right Axis Specification Proximal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Gene Expression Forebrain Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Glomerular Capillary Formation
Pathways		Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing Signaling by NOTCH3
Drugs
Diseases
GWAS		Type 1 diabetes ( 21980299)
Protein-Protein Interactions		10 interactors: ADAM10 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 NOV POFUT1 PSEN1	40 interactors: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B MAML1 MAML2 MAML3 MPPED2 MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		28514	4854
HPRD ID		05957	02607
Ensembl ID		ENSG00000198719	ENSG00000074181
Uniprot IDs		O00548	Q9UM47
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Pathway Nervous System Development Anatomical Structure Morphogenesis Pattern Specification Process Blood Vessel Development Vasculature Development Epithelium Development Glomerulus Development Cell Surface Receptor Signaling Pathway Cell Fate Commitment Multicellular Organismal Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Interleukin-4 Production Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Generation Of Neurons Cardiovascular System Development Developmental Process Neurogenesis Membrane Protein Ectodomain Proteolysis Tissue Development Nephron Development System Development Cell Development Embryonic Limb Morphogenesis Myeloid Dendritic Cell Differentiation Glomerulus Vasculature Development Morphogenesis Of An Epithelium Heart Development Transcription Initiation From RNA Polymerase II Promoter Organ Development Myeloid Dendritic Cell Activation Neuron Differentiation Limb Morphogenesis Regulation Of Neuron Differentiation Embryo Development Negative Regulation Of Neuron Differentiation Limb Development Regulation Of Cell Migration Membrane Protein Proteolysis Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Morphogenesis Regulation Of Cell Motility	Notch Signaling Pathway Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Tissue Morphogenesis DNA-templated Transcription, Initiation Morphogenesis Of An Epithelium Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Epithelium Development Positive Regulation Of Metabolic Process Immune System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression System Development Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Hemopoiesis Cell Surface Receptor Signaling Pathway Anatomical Structure Development Cell Fate Commitment Developmental Process Tube Development Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Cell Differentiation Organ Morphogenesis Auditory Receptor Cell Differentiation Heart Morphogenesis Epithelial Tube Morphogenesis Membrane Protein Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Transcription Of Notch Receptor Target Hair Cell Differentiation Auditory Receptor Cell Fate Commitment Stem Cell Development Tube Morphogenesis Myoblast Differentiation Cell Development Endothelial Tube Morphogenesis Generation Of Neurons Notch Signaling Involved In Heart Development Amyloid Precursor Protein Catabolic Process Nervous System Development Stem Cell Maintenance Negative Regulation Of Cell Differentiation Stem Cell Differentiation Inner Ear Receptor Cell Differentiation
Tagcloud ?		ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Difference) ?		ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch1 pericytes played potentiate regenerate regenerative satellite tuning	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Intersection) ?		notch