DLL1 and CCN3

Number of citations of the paper that reports this interaction (PubMedID 12050162)
0

Data Source:
HPRD (in vitro, in vivo)

		DLL1	CCN3
Description		delta like canonical Notch ligand 1	cellular communication network factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Raft Anchoring Junction	Extracellular Region Extracellular Space Cytoplasm Cytosol Gap Junction Extracellular Matrix Anchoring Junction
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Tat Protein Binding Receptor Ligand Activity Scaffold Protein Binding	Signaling Receptor Binding Notch Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Heparin Binding
	Biological Process	Cell Fate Determination Somitogenesis Somite Specification Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Marginal Zone B Cell Differentiation Type B Pancreatic Cell Development Cell Communication Notch Signaling Pathway Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Astrocyte Development Regulation Of Somitogenesis Spinal Cord Development Cerebellar Molecular Layer Formation Cerebellar Purkinje Cell Layer Structural Organization Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-10 Production Negative Regulation Of Glial Cell Apoptotic Process Organ Growth Regulation Of Growth Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Lateral Inhibition Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Neuron Fate Specification Inner Ear Development Regulation Of Neurogenesis Regulation Of Cell Division Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Neuroepithelial Cell Differentiation Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Left/right Axis Specification Nephron Development Proximal Tubule Development Loop Of Henle Development Clathrin-dependent Endocytosis Energy Homeostasis Endothelial Tip Cell Fate Specification Neuronal Stem Cell Population Maintenance Skin Epidermis Development Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Cell Differentiation	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus MECP2 regulates transcription of neuronal ligands Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of paraxial mesoderm Somitogenesis Nephron development
Drugs			Insulin human
Diseases
GWAS		Interferon alpha levels in systemic lupus erythematosus ( 25338677) Intraocular pressure ( 29785010) Plasma anti-thyroglobulin levels ( 29678681) Type 1 diabetes ( 21980299)
Interacting Genes		10 interacting genes: ADAM10 CCN3 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 POFUT1 PSEN1	31 interacting genes: ADSL ANKRD11 APOL6 C11orf87 CCN2 CDKN1A COL8A1 DLL1 FAM90A1 FBLN1 FN1 FRS3 FXR1 FXR2 GJA1 HOXA1 IGF1 IGF2 INS ITGAV KRTAP5-6 LCE1A LCE3D NID2 NOTCH1 POLR2L POU4F2 RECK S100A4 TNIP3 ZNF330
Entrez ID		28514	4856
HPRD ID		05957	01291
Ensembl ID		ENSG00000198719	ENSG00000136999
Uniprot IDs		A0A384P5C6 O00548	P48745
PDB IDs		4XBM
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Regulation Of Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Golgi Membrane Angiogenesis Protein Catabolic Process At Postsynapse Cellular Response To Tumor Cell Regulation Of Signal Transduction Pattern Specification Process Positive Regulation Of Notch Signaling Pathway Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Forebrain Development Marginal Zone B Cell Differentiation Cell Surface Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Limb Morphogenesis Podocyte Development Tube Morphogenesis Cell Surface Receptor Signaling Pathway Limb Morphogenesis Left/right Axis Specification Epithelial Tube Morphogenesis Amyloid Precursor Protein Catabolic Process Lymphocyte Activation Involved In Immune Response Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Myotube Differentiation Myeloid Leukocyte Activation Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Myeloid Dendritic Cell Differentiation Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Membrane Protein Ectodomain Proteolysis Notch Binding Amyloid Precursor Protein Metabolic Process Leukocyte Activation Involved In Immune Response Regulation Of Muscle Cell Differentiation Cell Activation Involved In Immune Response Renal Tubule Development Anterior/posterior Pattern Specification Myeloid Dendritic Cell Activation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mature B Cell Differentiation Involved In Immune Response	Tissue Development Epidermis Development Integrin Binding Positive Regulation Of Growth Positive Regulation Of Developmental Growth Regulation Of Growth Regulation Of Developmental Growth Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Receptor Ligand Activity Insulin-like Growth Factor Receptor Binding Positive Regulation Of Glycogen Biosynthetic Process Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Cell Development Regulation Of Nervous System Development Insulin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Gene Expression Angiogenesis Positive Regulation Of Cell Differentiation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Regulation Of Glycogen Biosynthetic Process Basement Membrane Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Response To Wounding Extracellular Region Positive Regulation Of Cell Communication Positive Regulation Of Signaling Integrin-mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Endodermal Cell Differentiation Positive Regulation Of D-glucose Import Cell-matrix Adhesion Regulation Of Neurogenesis Regulation Of Glycogen Metabolic Process Regulation Of Somitogenesis Positive Regulation Of Neurogenesis Regulation Of Skeletal Muscle Tissue Growth
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