DLL1 and MAGI2

Number of citations of the paper that reports this interaction (PubMedID 14529612)
0

Data Source:
HPRD (two hybrid, in vitro)

		DLL1	MAGI2
Description		delta like canonical Notch ligand 1	membrane associated guanylate kinase, WW and PDZ domain containing 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Raft Anchoring Junction	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Late Endosome Centrosome Centriole Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Postsynaptic Density Membrane Dendrite Protein-containing Complex Slit Diaphragm Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Ciliary Base
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Tat Protein Binding Receptor Ligand Activity Scaffold Protein Binding	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Cell Fate Determination Somitogenesis Somite Specification Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Marginal Zone B Cell Differentiation Type B Pancreatic Cell Development Cell Communication Notch Signaling Pathway Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Astrocyte Development Regulation Of Somitogenesis Spinal Cord Development Cerebellar Molecular Layer Formation Cerebellar Purkinje Cell Layer Structural Organization Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-10 Production Negative Regulation Of Glial Cell Apoptotic Process Organ Growth Regulation Of Growth Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Lateral Inhibition Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Neuron Fate Specification Inner Ear Development Regulation Of Neurogenesis Regulation Of Cell Division Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Neuroepithelial Cell Differentiation Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Left/right Axis Specification Nephron Development Proximal Tubule Development Loop Of Henle Development Clathrin-dependent Endocytosis Energy Homeostasis Endothelial Tip Cell Fate Specification Neuronal Stem Cell Population Maintenance Skin Epidermis Development Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Cell Differentiation	Positive Regulation Of Receptor Internalization Endocytosis Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Podocyte Development Clathrin-dependent Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus MECP2 regulates transcription of neuronal ligands Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of paraxial mesoderm Somitogenesis Nephron development	Nephrin family interactions
Drugs
Diseases
GWAS		Interferon alpha levels in systemic lupus erythematosus ( 25338677) Intraocular pressure ( 29785010) Plasma anti-thyroglobulin levels ( 29678681) Type 1 diabetes ( 21980299)	Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Airway wall thickness ( 25517131) Bitter beverage consumption ( 31046077) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Bronchopulmonary dysplasia ( 23897914) Chronotype ( 30696823) Computer vision syndrome ( 33941792) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) General risk tolerance (MTAG) ( 30643258) Hippocampal atrophy ( 19668339) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Low density lipoprotein cholesterol levels ( 33339817) Mammographic density (dense area) ( 25342443) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Nicotine dependence ( 33144568) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to anti-depressant treatment in major depressive disorder ( 22041458) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Schizophrenia ( 30285260 28991256) Serum folate levels ( 29953918) Total cholesterol levels ( 33339817) Visceral fat ( 30942860)
Interacting Genes		10 interacting genes: ADAM10 CCN3 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 POFUT1 PSEN1	30 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAM DSCAML1 DYRK3 GRID2 LCOR MORN4 PDZD11 PLEKHF2 PLXNB3 PRRG4 PTEN RAPGEF2 RIPK4 RPS6KA1 SMAD3 SNRPB TGFA VANGL2
Entrez ID		28514	9863
HPRD ID		05957	16212
Ensembl ID		ENSG00000198719	ENSG00000187391
Uniprot IDs		A0A384P5C6 O00548	B7Z4H4 Q86UL8
PDB IDs		4XBM	1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Regulation Of Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Golgi Membrane Angiogenesis Protein Catabolic Process At Postsynapse Cellular Response To Tumor Cell Regulation Of Signal Transduction Pattern Specification Process Positive Regulation Of Notch Signaling Pathway Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Forebrain Development Marginal Zone B Cell Differentiation Cell Surface Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Limb Morphogenesis Podocyte Development Tube Morphogenesis Cell Surface Receptor Signaling Pathway Limb Morphogenesis Left/right Axis Specification Epithelial Tube Morphogenesis Amyloid Precursor Protein Catabolic Process Lymphocyte Activation Involved In Immune Response Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Myotube Differentiation Myeloid Leukocyte Activation Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Myeloid Dendritic Cell Differentiation Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Membrane Protein Ectodomain Proteolysis Notch Binding Amyloid Precursor Protein Metabolic Process Leukocyte Activation Involved In Immune Response Regulation Of Muscle Cell Differentiation Cell Activation Involved In Immune Response Renal Tubule Development Anterior/posterior Pattern Specification Myeloid Dendritic Cell Activation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mature B Cell Differentiation Involved In Immune Response	PDZ Domain Binding Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Junction Assembly Synapse Synapse Organization Regulation Of Nervous System Development Chemical Synaptic Transmission Cell Junction Organization Signaling Postsynaptic Specialization Trans-synaptic Signaling Synaptic Signaling Postsynaptic Density Anchoring Junction System Development Regionalization Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Communication Anatomical Structure Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Cell-cell Junction Synapse Assembly Developmental Process Cell-cell Adhesion Mediator Activity Regulation Of Neurogenesis Glutamatergic Synapse Epithelial Tube Morphogenesis Nervous System Development Regulation Of Striated Muscle Tissue Development Cell Fate Determination Positive Regulation Of Developmental Process Pattern Specification Process Heat Generation Hepatocyte Proliferation Regulation Of Growth Regulation Of Muscle Organ Development Osteoblast Differentiation Gastrulation Embryonic Morphogenesis Animal Organ Development Positive Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cell Junction Assembly Transcription Corepressor Binding Regulation Of Multicellular Organismal Development
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