ACLY and HGS

Number of citations of the paper that reports this interaction (PMID 19019082)
2

Data Source:
BioGRID (pull down)

		ACLY	HGS
Gene Name		ATP citrate lyase	hepatocyte growth factor-regulated tyrosine kinase substrate
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Citrate Lyase Complex Membrane Extracellular Vesicular Exosome	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	ATP Citrate Synthase Activity Succinate-CoA Ligase (ADP-forming) Activity Protein Binding ATP Binding Metal Ion Binding Cofactor Binding	Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Citrate Metabolic Process Energy Reserve Metabolic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways		Fatty Acyl-CoA Biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Integration of energy metabolism ChREBP activates metabolic gene expression Triglyceride Biosynthesis	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Eye color traits ( 20463881)
Protein-Protein Interactions		5 interactors: APP CDKN2A GSK3B HGS PRKACA	138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302
Entrez ID		47	9146
HPRD ID		00155	05085
Ensembl ID		ENSG00000131473	ENSG00000185359
Uniprot IDs		B4E3P0 P53396	O14964
PDB IDs		3MWD 3MWE 3PFF	2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Binding Positive Regulation Of Protein Export From Nucleus Regulation Of Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Process Negative Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Binding Regulation Of Intracellular Protein Transport Apoptotic Process Regulation Of Cardiac Muscle Hypertrophy Programmed Cell Death Positive Regulation Of Cell Cycle Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Positive Regulation Of Proteolysis Cell Death Death Negative Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process	Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance
Tagcloud ?		anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?