ACLY

Description		ATP citrate lyase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Cytosol Membrane Azurophil Granule Lumen Ciliary Basal Body Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Catalytic Activity ATP Citrate Synthase Activity Protein Binding ATP Binding Transferase Activity Metal Ion Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer
	Biological Process	Acetyl-CoA Biosynthetic Process Citrate Metabolic Process Oxaloacetate Metabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Negative Regulation Of Ferroptosis
Pathways		ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis
Drugs		Bempedoic acid
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		10 interacting genes: APP CDKN2A CEBPA DDIAS FXR1 GSK3B HGS KLHL25 PRKACA USP7
Entrez ID		47
HPRD ID		00155
Ensembl ID		ENSG00000131473
Uniprot IDs		P53396
PDB IDs		3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET 6HXH 6HXK 6HXL 6HXM 6O0H 6POE 6POF 6QFB 6UI9 6UIA 6UUW 6UUZ 6UV5 6Z2H 7LIW 7LJ9 7LLA 7RIG 7RKZ 7RMP 8G1E 8G1F 8G5C 8G5D
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Regulation Of Long-term Synaptic Potentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Proteasomal Protein Catabolic Process Postsynapse Regulation Of Developmental Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process P53 Binding Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intracellular Transport TOR Signaling Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Gene Expression Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Developmental Process Regulation Of Circadian Rhythm Negative Regulation Of Small Molecule Metabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Translation Intracellular Signaling Cassette Regulation Of Gene Expression Negative Regulation Of Signaling Positive Regulation Of Cell Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Proteolysis Regulation Of Intracellular Protein Transport
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