ACLY

Gene Name		ATP citrate lyase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Citrate Lyase Complex Membrane Extracellular Vesicular Exosome
	Molecular Function	ATP Citrate Synthase Activity Succinate-CoA Ligase (ADP-forming) Activity Protein Binding ATP Binding Metal Ion Binding Cofactor Binding
	Biological Process	Citrate Metabolic Process Energy Reserve Metabolic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Fatty Acyl-CoA Biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Integration of energy metabolism ChREBP activates metabolic gene expression Triglyceride Biosynthesis
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: APP CDKN2A GSK3B HGS PRKACA
Entrez ID		47
HPRD ID		00155
Ensembl ID		ENSG00000131473
Uniprot IDs		B4E3P0 P53396
PDB IDs		3MWD 3MWE 3PFF
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Binding Positive Regulation Of Protein Export From Nucleus Regulation Of Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Process Negative Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Binding Regulation Of Intracellular Protein Transport Apoptotic Process Regulation Of Cardiac Muscle Hypertrophy Programmed Cell Death Positive Regulation Of Cell Cycle Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Positive Regulation Of Proteolysis Cell Death Death Negative Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?		anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg