CCDC136 and NOP53

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC136	NOP53
Description		coiled-coil domain containing 136	NOP53 ribosome biogenesis factor
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Membrane Cytoplasmic Vesicle	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol RDNA Heterochromatin
	Molecular Function	Protein Binding	P53 Binding RNA Binding Protein Binding 5S RRNA Binding Identical Protein Binding
	Biological Process	Acrosome Assembly Spermatogenesis Single Fertilization Cell Differentiation	Ribosomal Large Subunit Assembly Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Phosphorylation DNA Repair RRNA Processing DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Ribosome Biogenesis Regulation Of Apoptotic Process Protein Stabilization Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Localization To Nucleolus Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Protein Localization To Nucleoplasm
Pathways
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		138 interacting genes: ABT1 AQP1 ATP5PO ATXN1 BARD1 BLOC1S6 BYSL C1orf216 C21orf58 CARD9 CBX8 CCDC120 CCDC13 CCDC146 CCDC185 CCDC187 CCDC6 CCHCR1 CDC5L CDK2AP1 CEP57 CEP57L1 CEP95 COIL CWF19L2 DDX6 DISC1 DTNB DYNC1I2 ENKD1 FAM107A FAM161A FAM161B FAM50B FLYWCH1 GFI1B HAUS1 HDAC4 HGS HMG20A HMG20B HOXB5 ISCU JAKMIP2 JMY JRK KANSL1 KAT5 KIF5B KIFC3 LCA5L LENG1 MAGEB4 MBD1 MBD3L2 MCRS1 MOS NDC80 NDN NEBL NEK6 NME7 NOP53 ODAD3 PDLIM5 PIBF1 PKN1 PKN2 POGZ PPP1R18 PRPF18 PRPF3 PRPF31 PRR35 PSMA1 PSMC5 PSMD9 RAB33A RAB33B RALBP1 RASAL3 RASSF8 SCNM1 SDHAF1 SHFL SMARCA2 SMARCE1 SYT6 TBRG1 TCEA2 TCEANC THAP7 TNNT1 TRAF3IP3 TSGA10 TSGA10IP TSPYL1 TXLNA UBQLN4 UBTFL1 USP2 WT1 ZBTB24 ZBTB38 ZBTB47 ZC2HC1C ZFP1 ZFYVE26 ZNF124 ZNF20 ZNF223 ZNF230 ZNF250 ZNF264 ZNF329 ZNF35 ZNF408 ZNF417 ZNF440 ZNF490 ZNF497 ZNF564 ZNF572 ZNF580 ZNF581 ZNF587 ZNF599 ZNF648 ZNF669 ZNF670 ZNF688 ZNF696 ZNF774 ZNF777 ZNF785 ZNF835 ZNF837 ZSCAN26	15 interacting genes: CCDC136 CDKN2A CEP70 CFTR GRSF1 HAP1 HMGB2 OGT PPP1CA PSMA1 SPTBN1 SRPK2 TP53 TSPYL2 UPF2
Entrez ID		64753	29997
HPRD ID		10887	16142
Ensembl ID		ENSG00000128596	ENSG00000105373
Uniprot IDs		C9JU31 Q96JN2	Q9NZM5
PDB IDs			8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FLA 8FLB 8FLD 8FLE 8INE 8INF 8IPX 8IPY 8IR3
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Centrosome Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding Regulation Of Metabolic Process Cytoskeleton Chromatin Organization Microtubule-based Process Cilium Organization Nuclear Speck Microtubule Binding Spindle Pole Organelle Assembly Nuclear Proteasome Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding Nucleoplasm Regulation Of Sister Chromatid Segregation Cellular Component Assembly Microtubule Cytoskeleton Organization DNA-binding Transcription Factor Activity Centriole Protein Localization To Nucleoplasm Establishment Of Spindle Orientation Microtubule Double-stranded Methylated DNA Binding Cytosolic Proteasome Complex Centriolar Satellite Regulation Of Chromosome Segregation Regulation Of Protein Sumoylation Non-motile Cilium Assembly Histone Acetyltransferase Complex Ciliary Basal Body Establishment Of Spindle Localization	Nucleolus 14-3-3 Protein Binding Autophagy Of Mitochondrion Protein-containing Complex Cytoplasm Regulation Of Carbohydrate Catabolic Process Regulation Of Cellular Localization Nucleus Organization Organelle Organization MDM2/MDM4 Family Protein Binding Replicative Senescence Developmental Process Regulation Of Glucose Metabolic Process Nuclear Body Organization Autophagy RRNA Transcription Entrainment Of Circadian Clock By Photoperiod Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Negative Regulation Of DNA Replication Disordered Domain Specific Binding Negative Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Gene Expression Cellular Component Assembly Negative Regulation Of Cell Growth Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Cellular Component Organization Anatomical Structure Formation Involved In Morphogenesis Regulation Of Programmed Necrotic Cell Death Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transporter Activity Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Growth Nucleic Acid Metabolic Process RNA Metabolic Process Ligase Inhibitor Activity Regulation Of Cell Communication Nucleus Regulation Of Signaling Catabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Double-strand Break Repair Negative Regulation Of Helicase Activity
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