MT-ATP6 and GLP1R

Number of citations of the paper that reports this interaction (PubMedID 28597972)
0

Data Source:
BioGRID (protein complementation assay)

		MT-ATP6	GLP1R
Description		ATP synthase F0 subunit 6	glucagon like peptide 1 receptor
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Proton-transporting ATP Synthase Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton Channel Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity
	Biological Process	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Response To Hyperoxia Proton Transmembrane Transport	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress
Pathways		Formation of ATP by chemiosmotic coupling Mitochondrial translation termination Cristae formation Mitochondrial protein degradation	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate	Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS			Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)
Interacting Genes		3 interacting genes: CPEB2 FANCC GLP1R	112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99
Entrez ID		4508	2740
HPRD ID		02472	00677
Ensembl ID		ENSG00000198899	ENSG00000112164
Uniprot IDs		P00846 Q0ZFE3	A0A142FHB8 P43220
PDB IDs		8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3	3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Negative Regulation Of Cytoplasmic Translational Elongation Response To Psychosocial Stress Response To Peptide Hormone Negative Regulation Of Translational Elongation Cellular Response To Hormone Stimulus Fanconi Anaemia Nuclear Complex Post-translational Protein Targeting To Membrane, Translocation Positive Regulation Of Lyase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Adenylate Cyclase Activity Activation Of Adenylate Cyclase Activity Positive Regulation Of Cyclase Activity Response To Glucagon Response To Hormone Translation Factor Activity, RNA Binding GTPase Inhibitor Activity Negative Regulation Of Cytoplasmic Translation Ribosomal Small Subunit Binding MRNA Regulatory Element Binding Translation Repressor Activity Ribosomal Large Subunit Binding Regulation Of Translational Elongation Translation Regulator Activity MRNA 3'-UTR AU-rich Region Binding Intracellular Protein Transmembrane Transport Positive Regulation Of Blood Pressure Response To Stress Regulation Of Cytoplasmic Translation Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Interstrand Cross-link Repair Cellular Response To Oxygen-containing Compound Negative Regulation Of Blood Pressure Nucleotide-excision Repair Ribosome Binding Protein Transmembrane Transport	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration
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