MSH2 and RPA4

Number of citations of the paper that reports this interaction (PMID 19468048)
25

Data Source:
BioGRID (pull down)

		MSH2	RPA4
Gene Name		mutS homolog 2	replication protein A4, 30kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleoplasm Membrane MutSalpha Complex MutSbeta Complex	Nucleus Nucleoplasm DNA Replication Factor A Complex
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Heteroduplex DNA Loop Binding Double-strand/single-strand DNA Junction Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding	Single-stranded DNA Binding
	Biological Process	Meiotic Mismatch Repair In Utero Embryonic Development Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair Meiotic Gene Conversion Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Negative Regulation Of Reciprocal Meiotic Recombination Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Nucleotide-excision Repair DNA Recombination Nuclear DNA Replication
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	G1/S Transition Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ANXA7 ATR BARD1 BRCA1 CDKN1A CHEK2 CREBBP ESR1 ESR2 EXO1 GRB7 HUS1 MAX MSH3 MSH6 PCNA RAD1 RAD9A RPA4 RPP14 SMC1A SMN1 TK1 TREX1 XPA	7 interactors: APP MSH2 MSH3 MUTYH RPA1 RPA3 XPA
Entrez ID		4436	29935
HPRD ID		00389	06591
Ensembl ID		ENSG00000095002	ENSG00000204086
Uniprot IDs		E9PHA6 P43246	Q13156
PDB IDs		2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Damage Checkpoint Cell Cycle Process Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Ionizing Radiation Response To Abiotic Stimulus DNA Replication Negative Regulation Of DNA Metabolic Process Response To Stimulus Mismatch Repair Cellular Response To Ionizing Radiation Cellular Response To Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Catabolic Process, Exonucleolytic Negative Regulation Of DNA Replication Regulation Of DNA Replication Response To UV Developmental Process DNA Catabolic Process Cellular Response To Radiation Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Mitotic Cell Cycle Checkpoint Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Meiotic Cell Cycle Cellular Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Meiotic Mismatch Repair Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins	Mismatch Repair DNA Repair Nucleotide-excision Repair, DNA Damage Removal Cellular Response To DNA Damage Stimulus DNA Catabolic Process DNA Metabolic Process Meiotic Mismatch Repair DNA Recombination Maintenance Of DNA Repeat Elements Cellular Response To Stress Base-excision Repair DNA Recombinase Assembly Positive Regulation Of Helicase Activity Response To Stress Nucleotide-excision Repair Response To Abiotic Stimulus Aromatic Compound Catabolic Process Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Metabolic Process Meiotic Nuclear Division Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of DNA Recombination Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Meiotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Nitrogen Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Light Stimulus Chromosome Organization Reproduction Cell Cycle Process Cellular Response To Stimulus Immunoglobulin Production Cellular Response To Heat Regulation Of DNA Recombination Regulation Of Mitotic Cell Cycle Telomere Maintenance Response To Radiation
Tagcloud ?		adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Difference) ?		adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Intersection) ?